β-Triketone Nitisinone yica imibu irwanya udukoko binyuze mu kwinjiza uruhu | Udukoko n'udukoko

   Udukoko twica udukokoUbudahangarwa bw’udukoko twandura indwara z’ubuhinzi, amatungo n’ubuzima rusange bubangamira cyane gahunda zo kurwanya udukoko ku isi. Ubushakashatsi bwakozwe mbere bwagaragaje ko udukoko twandura amaraso dupfa cyane iyo dufashe amaraso arimo imiti igabanya ubukana bwa 4-hydroxyphenylpyruvate dioxygenase (HPPD), enzyme ya kabiri mu mikorere ya tyrosine. Ubu bushakashatsi bwasuzumye akamaro k’imiti igabanya ubukana bwa β-triketone HPPD mu kurwanya ubwoko butatu bw’indwara ziterwa n’imiti, harimo imibu yanduza indwara za kera nka malariya, indwara zisubira inyuma nka dengue na Zika, hamwe na virusi zivuka nka virusi za Oropuche na Usutu.

Itandukaniro riri hagati y'uburyo bwo gukoresha imiti yo mu bwoko bwa tarsal, tarsal n'icupa, uburyo bwo kuyikoresha, uburyo bwo kuyikoresha n'igihe ikoreshwa.
Ariko, nubwo hari itandukaniro mu rupfu hagati ya New Orleans na Muheza ku gipimo cyo hejuru, izindi ngaruka zose zari nziza cyane muri New Orleans (zishobora kwangirika) kurusha Muheza (zidakira) mu masaha 24.
Ibisubizo byacu bigaragaza ko nitisinone yica imibu inyunyuza amaraso binyuze mu gukorana na transtarsal, mu gihe mesotrione, sulfotrione, na tepoxiton bitayitandukanya. Ubu buryo bwo kwica ntibutandukanya ubwoko bw'imibu ishobora kwangirika cyangwa irwanya cyane izindi nganda z'imiti yica udukoko, harimo pyrethroids, organochlorines, ndetse na carbamate. Byongeye kandi, akamaro ka nitisinone mu kwica imibu binyuze mu gufata epidermal ntigagarukira ku bwoko bwa Anopheles gusa, nk'uko bigaragazwa n'ubushobozi bwayo kuri Strongyloides quinquefasciatus na Aedes aegypti. Amakuru yacu ashyigikira ko hakenewe ubushakashatsi bwimbitse kugira ngo nitisinone inyurwe neza, wenda binyuze mu kongera imiti mu gufata epidermal cyangwa kongeramo ibindi binyabutabire. Binyuze mu buryo bushya bwo gukora, nitisinone ikoresha imyitwarire yo gukurura amaraso y'imibu y'ingore. Ibi bituma iba umukandida mwiza wo gukoresha imiti mishya isigaye mu nzu n'insinga zica udukoko zimara igihe kirekire, cyane cyane mu turere aho uburyo gakondo bwo kurwanya imibu budakora neza bitewe no kugaragara vuba kwa pyrethroid.