β-Triketone Nitisinone Yica Imibu yica udukoko ikoresheje uruhu rwo gukuramo uruhu | Parasite na Vector

   Umuti wica udukokoKurwanya arthropods yanduza indwara z’ubuhinzi, ubuvuzi bw’amatungo n’ubuzima rusange bw’abaturage biteza akaga gakomeye kuri gahunda zo kurwanya indwara z’isi. Ubushakashatsi bwibanze bwerekanye ko arthropod yonsa amaraso ihura n’impfu nyinshi iyo yinjije amaraso arimo inhibitori ya 4-hydroxyphenylpyruvate dioxygenase (HPPD), enzyme ya kabiri muri metabolism ya tyrosine. Ubu bushakashatsi bwasuzumye imikorere ya β-triketone HPPD ibuza kurwanya indwara zanduza kandi zanduza pyrethroide y’indwara eshatu zikomeye, harimo imibu yanduza indwara z’amateka nka malariya, indwara zandura nka dengue na Zika, na virusi zigaragara nka virusi ya Oropuche na Usutu.

Itandukaniro hagati yuburyo bukoreshwa, tarsal na vial uburyo bwo gukoresha, uburyo bwo kubukoresha, gutanga udukoko twica udukoko nigihe cyibikorwa.
Nubwo, nubwo itandukaniro riri hagati yimfu hagati ya New Orleans na Muheza ku kigero kinini, ibindi byose byakusanyirijwe hamwe byagize ingaruka nziza muri New Orleans (susceptible) kuruta muri Muheza (irwanya) mu masaha 24.
Ibisubizo byacu byerekana ko nitisinone yica imibu yonsa amaraso ikoresheje transtarsal, mugihe mesotrione, sulfotrione, na tepoxiton bitica. Ubu buryo bwo kwica ntibutandukanya ubwoko bw imibu bworoshye cyangwa bwihanganira cyane ibindi byiciro byica udukoko, harimo pyrethroide, organochlorine, ndetse na karbamate. Byongeye kandi, ingaruka za nitisinone mu kwica imibu binyuze mu kwanduza epidermal ntizagarukira gusa ku bwoko bwa Anopheles, nk'uko bigaragazwa n’ingaruka zayo kuri Strongyloides quinquefasciatus na Aedes aegypti. Amakuru yacu ashyigikira ko hakenewe ubundi bushakashatsi kugirango hongerwemo nitisinone, bishoboka binyuze mu kongera imiti yo kwanduza epidermal cyangwa kongeramo imiti. Binyuze mu buryo bushya bwo gukora, nitisinone ikoresha imyitwarire yo kumena amaraso imibu y'abagore. Ibi bituma iba umukandida utanga ikizere cyo guhanga udushya dusize mu nzu hamwe ninshundura zica udukoko twica udukoko, cyane cyane mukarere aho usanga uburyo gakondo bwo kurwanya imibu butagira ingaruka kuberako hagaragara vuba kurwanya pyrethroide.