Chlormequat ni akugenzura imikurire yikimeraikoreshwa ryibihingwa byimbuto byiyongera muri Amerika ya ruguru. Ubushakashatsi bw’uburozi bwerekanye ko guhura na chlormequat bishobora kugabanya uburumbuke kandi bigatera ingaruka ku mwana ukura ku kigero kiri munsi y’imiti yemewe ya buri munsi yashyizweho n’inzego zibishinzwe. Hano, turatanga raporo ya chlormequat mu byitegererezo by'inkari byakusanyirijwe mu baturage ba Amerika, aho byagaragaye ko 69%, 74%, na 90% mu byitegererezo byakusanyijwe muri 2017, 2018–2022, na 2023. Kuva mu 2017 kugeza 2022, ubushakashatsi bwakozwe na chlormequat nkeya mu ngero, kandi guhera mu 2023, chlormequat yibanze ku ngero ziyongereye ku buryo bugaragara. Twabonye kandi ko chlormequat yabonetse kenshi mubicuruzwa bya oat. Ibi bisubizo hamwe namakuru yuburozi bwa chlormequat atera impungenge kurwego rwubu kandi arasaba ko hasuzumwa uburozi bwagutse, kugenzura ibiryo, n’ubushakashatsi bw’ibyorezo kugira ngo hamenyekane ingaruka ziterwa na chlormequat ku buzima bw’abantu.
Ubu bushakashatsi buvuga ko bwa mbere bwa chlormequat, ubuhinzi-mwimerere hamwe n’uburozi bw’iterambere n’imyororokere, mu baturage ba Amerika ndetse no mu biribwa byo muri Amerika. Mugihe urwego nkurwo rwimiti rwabonetse mubisubizo byinkari kuva 2017 kugeza 2022, urwego rwo hejuru rwagaragaye cyane muri 2023. Uyu murimo ugaragaza ko hakenewe gukurikiranwa mu buryo bwagutse chlormequat mu biribwa no ku ngero z’abantu muri Amerika, ndetse n’uburozi n’uburozi. Icyorezo cya Epidemiologiya ya chlormequat, kubera ko iyi miti ari umwanda ugaragara ufite ingaruka mbi ku buzima ku kigero gito mu bushakashatsi bw’inyamaswa.
Chlormequat ni imiti y’ubuhinzi yanditswe bwa mbere muri Amerika mu 1962 nkumuyobozi ushinzwe imikurire y’ibihingwa. Nubwo muri iki gihe yemerewe gukoreshwa gusa ku bimera by'imitako muri Amerika, icyemezo cya 2018 cyo muri Amerika gishinzwe kurengera ibidukikije (EPA) cyemereye kwinjiza ibicuruzwa by’ibiribwa (cyane cyane ibinyampeke) bivurwa na chlormequat [1]. Muri EU, Ubwongereza na Kanada, chlormequat yemerewe gukoreshwa ku bihingwa byibiribwa, cyane cyane ingano, oati na sayiri. Chlormequat irashobora kugabanya uburebure bwuruti, bityo bikagabanya amahirwe yo guhindagurika, bigatuma gusarura bigorana. Mu Bwongereza no mu bihugu by’Uburayi, muri rusange chlormequat ni ibisigisigi byica udukoko twangiza udukoko twangiza ibinyampeke n’ibinyampeke, nkuko byanditswe mu bushakashatsi bwakozwe mu gihe kirekire [2, 3].
Nubwo chlormequat yemerewe gukoreshwa ku bihingwa mu bice by’Uburayi na Amerika ya Ruguru, irerekana imiterere y’uburozi ishingiye ku bushakashatsi bw’inyamaswa bw’ubushakashatsi kandi buherutse gutangazwa. Ingaruka ziterwa na chlormequat ku burozi bw’imyororokere n’uburumbuke bwavuzwe bwa mbere mu ntangiriro y’imyaka ya za 1980 n’abahinzi b’ingurube bo muri Danemarike bagaragaje ko igabanuka ry’imyororokere y’ingurube zororerwa ku ngano zavuwe na chlormequat. Izi nyigisho zaje gusuzumwa mu bushakashatsi bwa laboratoire bwagenzuwe ku ngurube n'imbeba, aho ingurube z’abagore zagaburiraga ingano zivuwe na chlormequat zagaragaje imvururu muri cycle estrous no guhuza ugereranije n’inyamaswa ziyobora zagaburiwe indyo idafite chlormequat. Byongeye kandi, imbeba zabagabo zanduye chlormequat binyuze mubiryo cyangwa amazi yo kunywa mugihe cyiterambere byagaragaje ubushobozi buke bwo gufumbira intanga muri vitro. Ubushakashatsi bw’uburozi bw’imyororokere buherutse gukorwa kuri chlormequat bwerekanye ko guhura nimbeba kuri chlormequat mugihe cyiterambere cyiterambere, harimo gutwita ndetse nubuzima bwambere, byatumye ubwangavu butinda, kugabanuka kwintanga ngabo, kugabanya ibiro byimyororokere yumugabo, no kugabanuka kwa testosterone. Ubushakashatsi bw’uburozi bwiterambere bugaragaza kandi ko guhura na chlormequat mugihe utwite bishobora gutera imikurire y'inda no guhindagurika kwa metabolike. Ubundi bushakashatsi bwerekanye ko nta ngaruka za chlormequat ku mikorere y’imyororokere y’imbeba n’ingurube z’abagabo, kandi nta bushakashatsi bwakurikiyeho bwerekanye ingaruka za chlormequat ku burumbuke bw’imbeba z’abagabo zanduye chlormequat mu gihe cy’iterambere ndetse n’ubuzima bwa nyuma yo kubyara. Amakuru ahwanye na chlormequat mubuvanganzo bwuburozi ashobora guterwa no gutandukanya ibipimo byipimwa no gupimwa, hamwe no guhitamo ibinyabuzima byintangarugero nigitsina cyinyamaswa zigerageza. Kubera iyo mpamvu, irindi perereza riremewe.
Nubwo ubushakashatsi bwa toxicologique buherutse kwerekana ingaruka za chlormequat ku iterambere, imyororokere ndetse na sisitemu ya endocrine, uburyo izo ngaruka ziterwa n'uburozi ntibizwi. Ubushakashatsi bumwe bwerekana ko chlormequat idashobora gukora hakoreshejwe uburyo bwasobanuwe neza bwimiti yangiza endocrine, harimo na estrogene cyangwa reseptor ya androgene, kandi ntibihindura ibikorwa bya aromatase. Ibindi bimenyetso byerekana ko chlormequat ishobora gutera ingaruka muguhindura steroid biosynthesis no gutera endoplasmic reticulum.
Nubwo chlormequat iboneka hose mubiribwa bisanzwe byuburayi, umubare wubushakashatsi bwa biomonitoring bwerekana ko abantu bahura na chlormequat ni mbarwa. Chlormequat ifite ubuzima bucye mu mubiri, amasaha agera kuri 2-3, kandi mubushakashatsi bwakozwe nabakorerabushake bwabantu, dosiye nyinshi zigeragezwa zahanaguwe mumubiri mugihe cyamasaha 24. Muri rusange ingero z’abaturage baturutse mu Bwongereza no muri Suwede, chlormequat yagaragaye mu nkari z’abantu 100% bitabiriye ubushakashatsi ku muvuduko mwinshi no kwibanda ku zindi miti yica udukoko nka chlorpyrifos, pyrethroide, thiabendazole na metabolite ya mancozeb. Ubushakashatsi bwakozwe ku ngurube bwerekanye ko chlormequat ishobora no kuboneka muri serumu kandi ishobora kwimurirwa mu mata, ariko aya matrices ntabwo yigeze akorerwa ubushakashatsi ku bantu cyangwa ku zindi ngero z’inyamaswa zigerageza, nubwo kuba muri serumu n'amata bishobora kuba bifitanye isano n’imyororokere ituruka kuri imiti. . Hariho ingaruka zingenzi zo guhura mugihe utwite no mubana.
Muri Mata 2018, Ikigo cyo muri Amerika gishinzwe kurengera ibidukikije cyatangaje ko urwego rwo kwihanganira ibiribwa byemewe na chlormequat mu byatsi biva mu mahanga, ingano, sayiri, ndetse n’ibikomoka ku nyamaswa zimwe na zimwe, bituma chlormequat yinjizwa mu biribwa byo muri Amerika. Ibicuruzwa byemewe bya oat byiyongereye nyuma muri 2020. Kugira ngo hagaragazwe ingaruka z’ibi byemezo ku kuba no gukwirakwizwa kwa chlormequat mu baturage bakuze bo muri Amerika, ubu bushakashatsi bw’icyitegererezo bwapimye urugero rwa chlormequat mu nkari z’abantu baturutse mu turere dutatu two muri Amerika kuva mu 2017 kugeza 2023 na none muri 2022. hamwe na chlormequat yibirimo oat nibicuruzwa byaguzwe muri Amerika muri 2023.
Ingero zegeranijwe mu turere dutatu hagati ya 2017 na 2023 zakoreshejwe mu gupima urugero rw’inkari za chlormequat mu baturage ba Amerika. Ingero 21 z'inkari zegeranijwe ku bagore batwite batamenyekanye bemeye igihe cyo kubyara nk'uko byemezwa n'Inama ishinzwe isuzuma ry’ikigo cya 2017 (IRB) cyemejwe na kaminuza y’ubuvuzi ya Carolina yepfo (MUSC, Charleston, SC, USA). Ingero zabitswe kuri 4 ° C mu gihe cy’amasaha 4, hanyuma zigabanywa kandi zigakonja kuri -80 ° C. Ingero 25 z'inkari zikuze zaguzwe muri Lee Biosolutions, Inc (Maryland Heights, MO, USA) mu Gushyingo 2022, zerekana icyitegererezo kimwe cyegeranijwe kuva mu Kwakira 2017 kugeza muri Nzeri 2022, kandi cyegeranijwe n'abakorerabushake (abagabo 13 n'abagore 12). ) ku nguzanyo kuri Maryland Heights, icyegeranyo cya Missouri. Ingero zabitswe kuri -20 ° C ako kanya nyuma yo gukusanya. Byongeye kandi, ingero 50 z’inkari zegeranijwe n’abakorerabushake ba Florida (abagabo 25, abagore 25) muri Kamena 2023 zaguzwe muri BioIVT, LLC (Westbury, NY, USA). Ingero zabitswe kuri 4 ° C kugeza ubwo ingero zose zegeranijwe, hanyuma zigashyirwa hejuru hanyuma zigakonja kuri -20 ° C. Isosiyete itanga isoko yabonye ibyemezo bya IRB bikenewe kugirango itunganyirize abantu icyitegererezo kandi yemererwe gukusanya icyitegererezo. Nta makuru yihariye yatanzwe murimwe murugero rwageragejwe. Ingero zose zoherejwe zahagaritswe kugirango zisesengurwe. Ibisobanuro birambuye byamakuru murashobora kubisanga mugushyigikira amakuru Imbonerahamwe S1.
Umubare wa chlormequat mu nkari z’inkari z’abantu wagenwe na LC-MS / MS muri Laboratwari ya HSE (Buxton, mu Bwongereza) ukurikije uburyo bwashyizwe ahagaragara na Lindh n'abandi. Yahinduwe buhoro muri 2011. Muri make, ingero zateguwe zivanga 200 μl z'inkari zidashizwemo na 1.8 1.8 ya acetate ya 0.01 M amonium irimo ibipimo by'imbere. Icyitegererezo cyakuweho hifashishijwe inkingi ya HCX-Q, gishyirwa mbere na methanol, hanyuma hamwe na 0.01 M ametiyumu acetate, kwozwa na acetate ya 0.01 M amonium, hanyuma bivangwa na aside 1% ya metani. Ingero zahise zipakirwa ku nkingi ya C18 LC (Synergi 4 µ Hydro-RP 150 × 2 mm; Phenomenex, mu Bwongereza) hanyuma itandukanywa hakoreshejwe icyiciro cya mobile kigendanwa kigizwe na 0.1% aside aside: methanol 80:20 ku kigero cya 0.2. ml / min. Inzibacyuho yatoranijwe na mass spectrometry yasobanuwe na Lindh nabandi. 2011. Umupaka wo gutahura wari 0.1 μg / L nkuko byavuzwe muyindi nyigo.
Imyunyungugu ya chlormequat yinkari igaragazwa nka μmol chlormequat / mol creatinine hanyuma igahinduka μg chlormequat / g creatinine nkuko byavuzwe mubushakashatsi bwabanje (kugwiza 1.08).
Laboratoire ya Anresco, LLC yagerageje ibiryo by'ibiryo bya oats (25 bisanzwe na 8 organic) n'ingano (9 bisanzwe) kuri chlormequat (San Francisco, CA, USA). Ingero zasesenguwe hahinduwe hakurikijwe uburyo bwatangajwe [19]. LOD / LOQ kuburugero rwa oat muri 2022 no kuburugero rwingano na oat muri 2023 byashyizwe kuri 10/100 ppb na 3/40 ppb. Ibisobanuro birambuye byamakuru murashobora kubisanga mugushyigikira amakuru Imbonerahamwe S2.
Ubushuhe bwa chlormequat yinkari bwashyizwe hamwe n’ahantu hamwe n’umwaka byakusanyirijwemo, usibye ingero ebyiri zegeranijwe muri 2017 zivuye muri Maryland Heights, Missouri, zashyizwe hamwe n’izindi ngero za 2017 zaturutse i Charleston, muri Karoline y’Amajyepfo. Ingero ziri munsi yimipaka ya chlormequat zafashwe nkigice cyo gutahura kigabanijwe nu mizi ya kare ya 2. Amakuru ntiyari asanzwe akwirakwizwa, bityo ikizamini kidasanzwe cya Kruskal-Wallis hamwe na Dunn ikigereranyo cyo kugereranya cyakoreshejwe kugereranya abunzi hagati yitsinda. Ibiharuro byose byakorewe muri GraphPad Prism (Boston, MA).
Chlormequat yagaragaye muri 77 kuri 96 z'inkari, bingana na 80% by'inkari zose. Ugereranije na 2017 na 2018–2022, ingero 2023 zagaragaye kenshi: 16 kuri 23 (cyangwa 69%) na 17 kuri 23 (23%), na 45 kuri 50 (ni ukuvuga 90%) . ) barageragejwe (Imbonerahamwe 1). Mbere ya 2023, ubushakashatsi bwa chlormequat bwagaragaye muri ayo matsinda yombi bwari buhwanye, mu gihe ubushakashatsi bwa chlormequat bwagaragaye mu ngero za 2023 bwari hejuru cyane ugereranije n’ubushakashatsi bwakozwe mu myaka yashize (Ishusho 1A, B). Ikigereranyo gishobora kugaragara kuri 2017, 2018–2022, na 2023 ni 0.22 kugeza 5.4, 0.11 kugeza 4.3, na 0.27 kugeza 52.8 microgramu ya chlormequat kuri garama ya creinine. Indangagaciro yo hagati yingero zose muri 2017, 2018–2022, na 2023 ni 0.46, 0.30, na 1.4. Aya makuru yerekana ko guhura bishobora gukomeza bitewe nigihe gito cyubuzima bwa chlormequat mu mubiri, hamwe n’urwego rwo hasi rwagaragaye hagati ya 2017 na 2022 ndetse n’urwego rwo hejuru rwagaragaye muri 2023.
Ubwinshi bwa chlormequat kuri buri nkari yintangarugero yinkari itangwa nkikintu kimwe gifite utubari hejuru yikigereranyo hamwe namakosa yerekana +/- ikosa risanzwe. Ubushuhe bwa chlormequat yinkari bugaragarira muri mcg ya chlormequat kuri garama ya creinine ku gipimo cyumurongo hamwe na logarithmic. Isesengura ridasanzwe Kruskal-Wallis isesengura ryibitandukanya na Dunn ikigereranyo cyo kugereranya cyakoreshejwe mugupima akamaro k'imibare.
Ibyokurya byaguzwe muri Reta zunzubumwe zamerika muri 2022 na 2023 byerekanaga urugero rwa chlormequat murwego rwose usibye bibiri mubicuruzwa 25 bya oat gakondo, hamwe nibitekerezo biva kuri 291 μg / kg, byerekana chlormequat muri oati. Umubare w’ibikomoka ku bimera ni mwinshi. Ingero zegeranijwe muri 2022 na 2023 zifite impuzandengo isa: 90 µg / kg na 114 µg / kg. Icyitegererezo kimwe gusa cyibicuruzwa umunani bya oat kama byari bifite chlormequat igaragara ya 17 µg / kg. Twabonye kandi ubushyuhe buke bwa chlormequat muri bibiri mu bicuruzwa icyenda byapimwe ingano: 3.5 na 12,6 μg / kg.
Iyi ni raporo yambere yo gupima chlormequat yinkari ku bantu bakuru baba muri Amerika ndetse no mu baturage baturutse mu Bwongereza na Suwede. Imiti yica udukoko twangiza udukoko mu rubyiruko rusaga 1.000 muri Suwede yanditse igipimo cya 100% cya chlormequat kuva mu 2000 kugeza 2017. Ikigereranyo cy’ibanze muri 2017 cyari mikorobe 0.86 za chlormequat kuri garama ya creinine kandi bigaragara ko yagabanutse mu gihe, hamwe n’urwego rwo hejuru ugereranyije. kuba 2.77 muri 2009. Mu Bwongereza, biomonitoring yasanze ikigereranyo cya chlormequat kiri hejuru ya mikorobe 15.1 ya chlormequat kuri garama ya creinine hagati ya 2011 na 2012, nubwo izo ngero zegeranijwe ku bantu batuye mu buhinzi. nta tandukaniro ryagaragaye. Shira ibyabaye [15]. Ubushakashatsi bwakozwe ku cyitegererezo cy’Amerika kuva muri 2017 kugeza 2022 bwerekanye urwego rwo hagati ugereranije n’ubushakashatsi bwabanje mu Burayi, mu gihe mu 2023 urugero rw’icyitegererezo rwagereranijwe n’icyitegererezo cya Suwede ariko kiri munsi y’icyitegererezo cy’Ubwongereza.
Iri tandukaniro muguhura hagati yakarere nigihe cyigihe gishobora kwerekana itandukaniro mubikorwa byubuhinzi nuburyo imiterere ya chlormequat, amaherezo bigira ingaruka kurwego rwa chlormequat mubicuruzwa byibiribwa. Kurugero, intungamubiri za chlormequat mubyitegererezo byinkari zari hejuru cyane mumwaka wa 2023 ugereranije nimyaka yashize, zishobora kwerekana impinduka zijyanye nibikorwa bya EPA bijyanye na chlormequat (harimo n'ibiryo bya chlormequat muri 2018). Ibiribwa byo muri Amerika mugihe cya vuba. Kuzamura ibipimo bya oat bitarenze 2020.Ibikorwa byemerera kwinjiza no kugurisha ibicuruzwa byubuhinzi bivurwa na chlormequat, urugero, biva muri Kanada. Gutinda hagati y’imihindagurikire y’amabwiriza ya EPA hamwe n’ubwiyongere bukabije bwa chlormequat iboneka mu ngero z’inkari mu 2023 birashobora gusobanurwa n’ibihe byinshi, nko gutinda kwemeza imikorere y’ubuhinzi ikoresha chlormequat, gutinda kw’amasosiyete yo muri Amerika mu biganiro by’ubucuruzi, na abantu ku giti cyabo. barimo gutinda kugura oati kubera kugabanuka kwibicuruzwa bishaje kandi / cyangwa kubera igihe kirekire cyibicuruzwa bya oat.
Kugirango tumenye niba ubushakashatsi bwibanze ku nkari z’inkari zo muri Amerika bugaragaza ingaruka ziterwa n’imirire ya chlormequat, twapimye chlormequat muri oat n’ibicuruzwa by’ingano byaguzwe muri Amerika mu 2022 na 2023. Ibicuruzwa bya Oat birimo chlormequat inshuro nyinshi kuruta ibikomoka ku ngano, ndetse n’ubunini bwa chlormequat muri ibicuruzwa bitandukanye bya oat biratandukanye, hamwe nimpuzandengo ya 104 ppb, birashoboka bitewe nibitangwa na Amerika na Kanada, bishobora kwerekana itandukaniro mugukoresha cyangwa kubikoresha. hagati y'ibicuruzwa biva muri oati bivurwa na chlormequat. Ibinyuranye na byo, mu Bwongereza by’ibiribwa, chlormequat ni nyinshi mu bicuruzwa bishingiye ku ngano nk'umugati, hamwe na chlormequat yagaragaye muri 90% by'icyitegererezo cyakusanyirijwe mu Bwongereza hagati ya Nyakanga na Nzeri 2022. Ikigereranyo cyo hagati yacyo ni 60 ppb. Mu buryo nk'ubwo, chlormequat yagaragaye kandi muri 82% by'icyitegererezo cya oat yo mu Bwongereza ku kigereranyo cya 1650 ppb, ikubye inshuro zirenga 15 ugereranije n’icyitegererezo cyo muri Amerika, gishobora gusobanura ko inkari nyinshi zagaragaye mu ngero z’Ubwongereza.
Ibisubizo byacu bya biomonitoring byerekana ko guhura na chlormequat byabaye mbere ya 2018, nubwo kwihanganira imirire ya chlormequat bitashyizweho. Nubwo chlormequat itagenzurwa mu biribwa muri Amerika, kandi nta makuru y’amateka yerekeranye n'ubunini bwa chlormequat mu biribwa bigurishwa muri Amerika, urebye igice cya kabiri cy'ubuzima bwa chlormequat, turakeka ko uku guhura gushobora kuba ari indyo. Byongeye kandi, choline ibanziriza ibikomoka ku ngano nifu y amagi mubisanzwe ikora chlormequat mubushyuhe bwinshi, nkibikoreshwa mugutunganya ibiryo no kuyikora, bigatuma chlormequat yibanda kuri 5 kugeza 40 ng / g. Ibisubizo byacu byo gupima ibiryo byerekana ko ingero zimwe na zimwe, harimo n’ibicuruzwa biva mu binyabuzima, byarimo chlormequat ku rwego rusa n’ibyavuzwe mu bushakashatsi bwakozwe na chlormequat isanzwe ibaho, mu gihe izindi ngero nyinshi zarimo chlormequat nyinshi. Rero, urwego twabonye mu nkari kugeza mu 2023 rwashobokaga bitewe nimirire ya chlormequat yakozwe mugihe cyo gutunganya ibiryo no kuyikora. Urwego rwagaragaye mu 2023 rushobora guterwa no guhura nimirire ihura na chlormequat ubwayo hamwe nibicuruzwa bitumizwa mu mahanga bivurwa na chlormequat mubuhinzi. Itandukaniro muguhura kwa chlormequat murugero rwacu rishobora nanone guterwa na geografiya, imiterere yimirire itandukanye, cyangwa akazi ka chlormequat iyo ikoreshejwe muri pariki na pepiniyeri.
Ubushakashatsi bwacu bwerekana ko ingano nini yintangarugero hamwe nuburyo butandukanye bwibiryo bivurwa na chlormequat bikenewe kugirango dusuzume neza inkomoko yimirire ya chlormequat kubantu bafite ibibazo bike. Ubushakashatsi bw'ejo hazaza harimo gusesengura inkari n'amateka y'ibiribwa, ibibazo by’imirire n’akazi, gukurikirana buri gihe chlormequat mu biribwa bisanzwe n’ibinyabuzima muri Amerika, hamwe n’ibitegererezo bya biomonitoring bizafasha mu gusobanura ibintu bisanzwe biterwa na chlormequat mu baturage ba Amerika.
Kugeza ubu birashoboka ko urugero rwa chlormequat rwiyongera mu nkari hamwe n’ibiribwa muri Amerika mu myaka iri imbere. Muri Amerika, chlormequat yemerewe gusa mu bicuruzwa biva mu mahanga biva mu mahanga ndetse n’ingano, ariko ikigo gishinzwe kurengera ibidukikije kuri ubu kirimo gutekereza ku mikoreshereze y’ubuhinzi mu bihingwa bitari kama. Niba imikoreshereze nkiyi yo mu rugo yemerewe ifatanije n’ubuhinzi bukwirakwizwa na chlormequat mu mahanga ndetse no mu gihugu imbere, urugero rwa chlormequat muri oati, ingano, n’ibindi bicuruzwa by’ibinyampeke bishobora gukomeza kwiyongera, bigatuma urwego rwa chlormequat rwiyongera. Abaturage bose bo muri Amerika.
Kugeza ubu inkari za chlormequat muri ubu hamwe nubundi bushakashatsi zerekana ko abaterankunga bintangarugero ku giti cyabo bahuye na chlormequat kurwego rwombi ruri munsi y’ikigo cy’Amerika gishinzwe kurengera ibidukikije cyashyizwe ahagaragara (RfD) (0.05 mg / kg uburemere bw’umubiri ku munsi), bityo biremewe . Ifunguro rya buri munsi ni amabwiriza menshi yubunini buri munsi yagaciro kayo yatangajwe n’ikigo cy’uburayi gishinzwe umutekano w’ibiribwa (ADI) (0.04 mg / kg uburemere bwumubiri / umunsi). Ariko, twibutse ko ubushakashatsi bwerekeranye nuburozi bwa chlormequat bwerekana ko kongera gusuzuma ibipimo byumutekano bishobora kuba ngombwa. Kurugero, imbeba ningurube byerekanwe na dosiye iri munsi ya RfD na ADI (0.024 na 0.0023 mg / kg uburemere bwumubiri / kumunsi,) byagaragaje uburumbuke. Mu bundi bushakashatsi bw’uburozi, guhura n’igihe cyo gutwita ku kigero kingana n’urwego rutagaragaye (NOAEL) rwa 5 mg / kg (rukoreshwa mu kubara Ikigo cy’Amerika gishinzwe kurengera ibidukikije) cyagize ingaruka ku mikurire y’inda no guhinduranya metabolism, ndetse nkimpinduka mumiterere yumubiri. Imbeba za Neonatal. Byongeye kandi, ibipimo ngenderwaho ntibireba ingaruka mbi zivanze n’imiti ishobora kugira ingaruka ku myororokere, byagaragaye ko ifite ingaruka ziyongera cyangwa zikorana ku kigero kiri munsi y’imiti y’imiti, bigatera ibibazo by’ubuzima bw’imyororokere. ubuzima. Guhangayikishwa n'ingaruka zijyanye nurwego rugaragara, cyane cyane kubafite urwego rwo hejuru rugaragara mubaturage muri rusange muri Burayi no muri Amerika.
Ubu bushakashatsi bw’ubushakashatsi bwakozwe ku miti mishya muri Amerika bugaragaza ko chlormequat iboneka mu biribwa byo muri Amerika, cyane cyane mu bicuruzwa bya oat, ndetse no mu bice byinshi by’inkari byagaragaye byakusanyirijwe mu bantu bagera kuri 100 muri Amerika, byerekana ko chlormequat ikomeje guhura na byo. Byongeye kandi, imigendekere yaya makuru yerekana ko urwego rwerekanwe rwiyongereye kandi rushobora gukomeza kwiyongera mugihe kizaza. Urebye impungenge z'uburozi bujyanye no kwerekana chlormequat mu bushakashatsi bw’inyamaswa, no kuba abaturage muri rusange bakwirakwizwa na chlormequat mu bihugu by’Uburayi (ndetse no muri Amerika ubu), hamwe n’ubushakashatsi bw’ibyorezo n’inyamaswa, hakenewe byihutirwa Gukurikirana chlormequat muri ibiryo n'abantu Chlormequat. Ni ngombwa gusobanukirwa ingaruka zishobora guteza ubuzima bwiyi miti yubuhinzi kurwego rwibidukikije cyane cyane mugihe utwite.
Igihe cyo kohereza: Jun-04-2024