Florfenikolni ubwoko bwa monofluoro bukomoka kuri thiamphenicol, formula ya molekile ni C12H14Cl2FNO4S, ifu y'umweru cyangwa idafite umweru, nta mpumuro, ishonga gato cyane mu mazi na chloroform, ishonga gato muri aside glacial acetic, ishonga muri Methanol, ethanol. Ni antibiyotike nshya ya chloramphenicol ifite imiterere migari ikoreshwa mu buvuzi bw'amatungo, yakozwe neza mu mpera z'imyaka ya 1980.
Yatangiye kugurishwa mu Buyapani mu 1990. Mu 1993, Noruveje yemeje uyu muti wo kuvura furuncle ya salmon. Mu 1995, Ubufaransa, Ubwongereza, Otirishiya, Megizike na Esipanye bemeje uyu muti wo kuvura indwara za bagiteri z'ubuhumekero z'inka. Yemejwe kandi gukoreshwa nk'inyongera ku biryo by'ingurube mu Buyapani na Megizike mu gukumira no kuvura indwara za bagiteri mu ngurube, kandi Ubushinwa bwaremeje uyu muti.
Ni umuti urwanya udukoko, utanga ingaruka za bagiteri mu buryo bwagutse binyuze mu kubuza imikorere ya peptidyltransferase, kandi ufite ubwoko bwa bagiteri mu buryo bwagutse, harimo n'ubwoko butandukanyeGarama-positivena bagiteri mbi na mycoplasma. Bagiteri zoroshye zirimo ingurube na Haemophilus,Shigella dysenteriae, Salmonella, Escherichia coli, Pneumococcus, Influenza bacillus, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, nibindi. Iki gicuruzwa gishobora gukwirakwira mu tunyangingo twa bagiteri binyuze mu gushonga kwa lipide, ahanini gikora ku gice cy’urutonde rwa 50s rwa ribosome ya bagiteri yo mu myaka ya 70, kikabuza transpeptidase, kikabangamira ikura rya peptidase, kikabuza ikorwa rya peptide chains, bityo kikabuza poroteyine gukora, kikagera ku ntego ya Antibacterial. Iki gicuruzwa cyinjizwa vuba iyo kinyowe, kigakwirakwira hose, kimara igihe kirekire, gifite igice cy’ubuzima, gifite ingano nyinshi y’imiti mu maraso, kandi kikabasha gukomeza gukoresha imiti mu maraso.
Mu myaka ya vuba aha, ubworozi bwinshi bw'ingurube buto n'ubuciriritse bwakoresheje florfenicol mu kuvura hatitawe ku mimerere y'ingurube, kandi bwakoresheje florfenicol nk'umuti w'ubumaji. Mu by'ukuri, ibi ni bibi cyane. Bigira ingaruka nziza ku ndwara z'ingurube ziterwa na bagiteri za Gram-positive na negative na mycoplasma, cyane cyane nyuma yo kuvanga florfenicol na doxycycline, ingaruka ziyongera, kandi zigira akamaro mu kuvura urunigi rw'ingurube zo mu gituza ziterwa n'ingurube. Cocci, n'ibindi bivura neza.
Ariko, impamvu ari bibi gukoresha florfenicol buri gihe ni uko hari ingaruka nyinshi za florfenicol, kandi gukoresha florfenicol igihe kirekire bigira ingaruka mbi kurusha ibyiza. Urugero, inshuti z'ingurube ntizigomba kwirengagiza izi ngingo.
1. Niba hari indwara za virusi nka pseudorabies iterwa n'indwara y'ingurube ifite impeta y'ubururu mu bworozi bw'ingurube, gukoresha florfenicol mu kuvura akenshi bizatera iyi ndwara ya virusi, bityo niba indwara zavuzwe haruguru zanduye kandi zigakurikiraho. Iyo wanduye izindi ndwara z'ingurube, ntugakoreshe florfenicol mu kuvura, bizarushaho kongera ubukana bw'indwara.
2. Florfenicol izabangamira sisitemu yacu yo mu maraso kandi ikabuza ikorwa ry’uturemangingo dutukura mu igufwa, cyane cyane iyo ingurube zacu zonsa zifite ibicurane cyangwa ingingo zibyimbye. Ibara ry’ubwoya bw’ingurube si ubwoya bwiza, bukaranze, ariko kandi bugaragaza ibimenyetso byo kubura amaraso, bizatuma ingurube idakira igihe kirekire, bigatuma ikora ingurube ikomeye.
3. Florfenicol itera uburozi mu nda y'umwana. Iyo florfenicol ikunze gukoreshwa mu gihe cyo gutwita mu nda y'ingurube, ingurube zavuyemo zirapfa.
4. Gukoresha florfenicol igihe kirekire bizatera indwara zo mu gifu no gucibwamo mu ngurube.
5. Biroroshye gutera ubwandu bwa kabiri, nk'indwara ya exudative dermatitis iterwa n'ubwandu bwa staphylococcus mu ngurube cyangwa ubwandu bwa kabiri bwa dermatitis imwe n'imwe iterwa n'ibihumyo.
Muri make, florfenicol ntigomba gukoreshwa nk'umuti usanzwe. Iyo dukoresheje izindi antibiyotike zifite ingaruka mbi kandi mu buryo buvanze (kwirukana virusi), dushobora gukoresha florfenicol na doxycycline. Acupuncture ikoreshwa mu kuvura indwara zikomeye, kandi ntiyemerwa no mu bindi bihe.
Igihe cyo kohereza: Nyakanga-14-2022