Guhura na pyrethroide birashobora kongera ibyago byindwara ya Parkinson bitewe no gukorana na genetique binyuze mumubiri.
Pyrethroide iboneka mubucuruzi bwinshiimiti yica udukoko two mu rugo.Nubwo ari udukoko twangiza udukoko, muri rusange bifatwa nk’umutekano kugira ngo abantu babonane n’ubuyobozi bwa leta.
Guhindagurika kw'irondakoko hamwe n'imiti yica udukoko bigaragara ko bigira ingaruka ku ndwara ya Parkinson.Ubushakashatsi bushya busanga isano iri hagati yibi bintu byombi bishobora guteza ingaruka, ikagaragaza uruhare rw’ubudahangarwa bw'umubiri mu gutera indwara.
Ibyagaragaye bifitanye isano nicyiciro cyaimiti yica udukokobita pyrethroide, iboneka mu miti myinshi yica udukoko two mu rugo kandi ikoreshwa cyane mu buhinzi kuko iyindi miti yica udukoko ikurwaho.Nubwo pyrethroide ari neurotoxique y’udukoko, abategetsi ba leta muri rusange babona ko bafite umutekano ku bantu.
Ubu bushakashatsi ni bwo bwa mbere buhuza pyrethroide ihura n’ingaruka ziterwa n’indwara ya Parkinson ndetse ikanatanga ubushakashatsi bwo gukurikirana, nk'uko byatangajwe n’umwanditsi mukuru, Malu Tansi, Ph.D., umwungirije wungirije wa physiologiya mu ishuri ry’ubuvuzi rya Emory.
Ubwoko bwa genetike itsinda ryavumbuye ni mukarere katarangwamo code ya MHC II (major histocompatibility complex class II), itsinda rya genes zigenga sisitemu yumubiri.
Tansey yagize ati: "Ntabwo twari twiteze kubona umurongo wihariye na pyrethroide."“Birazwi ko guhura cyane na pyrethroide bishobora gutera ubudahangarwa bw'umubiri, kandi molekile zikora zishobora kuboneka mu ngirabuzimafatizo z'umubiri;Ubu dukeneye gusobanukirwa byinshi ku bijyanye no kumara igihe kirekire bigira ingaruka ku mikorere y’umubiri bityo bikazamura imikorere yacyo. ”Ibyago by'indwara ya Kinson. ”
“Hariho ibimenyetso bifatika byerekana ko gutwika ubwonko cyangwa sisitemu y'umubiri idakabije bishobora kugira uruhare mu gutera indwara ya Parkinson.Ati: “Turatekereza ko ibishobora kuba hano ari uko ibidukikije bishobora guhindura ubudahangarwa bw'umubiri ku bantu bamwe na bamwe, bigatuma ubwonko budakira mu bwonko.”
Kuri ubwo bushakashatsi, abashakashatsi ba Emory bayobowe na Tansey na Jeremy Boss, impamyabumenyi y'ikirenga, umuyobozi w'ishami rya Microbiology na Immunology, bafatanije na Stuart Factor, Ph.D., umuyobozi w'ikigo cy’indwara cya Emory's Comprehensive Parkinson, na Beate Ritz., MD, Kaminuza ya Californiya, San Francisco.Ku bufatanye n'abashakashatsi ku buzima rusange muri UCLA, Ph.D.Umwanditsi wa mbere wiyi ngingo ni George T. Kannarkat, MD.
Abashakashatsi ba UCLA bakoresheje ububiko bw’imiterere ya Californiya bukubiyemo imyaka 30 yo gukoresha imiti yica udukoko mu buhinzi.Bahisemo guhura bakurikije intera (akazi k'umuntu na aderesi y'urugo) ariko ntibapima urugero rwica udukoko mu mubiri.Pyrethroide yatekerejweho kwangirika vuba, cyane cyane iyo ihuye nizuba, hamwe nubuzima bwa kimwe cya kabiri mubutaka bwiminsi kugeza ibyumweru.
Mu ngingo 962 zo mu kibaya cyo hagati cya Kaliforuniya, ubwoko rusange bwa MHC II bufatanije n’ikigereranyo cyo hejuru cy’imiti yica udukoko twangiza pyrethroide byongera ibyago byo kwandura Parkinson.Ubwoko bubi cyane bwa gene (abantu bitwaje ibyago bibiri alleles) wasangaga 21% byabarwayi bafite indwara ya Parkinson na 16% byigenzura.
Muri iri tsinda, guhura na gene cyangwa pyrethroid byonyine ntabwo byongereye cyane ibyago byo kwandura indwara ya Parkinson, ariko guhuza kwabo.Ugereranije n'ikigereranyo, abantu bahuye na pyrethroide kandi bitwaje ibyago byinshi byo mu bwoko bwa MHC II bafite ibyago byinshi byo kwandura indwara ya Parkinson inshuro 2.48 kurusha abadafite ibibazo bike kandi bitwaje ingaruka nke za gene.ibyago.Guhura nubundi bwoko bwimiti yica udukoko, nka organofosifate cyangwa paraquat, ntabwo byongera ibyago muburyo bumwe.
Ubushakashatsi bunini bw'irondakoko, harimo na Factor n'abarwayi be, bwabanje guhuza imiterere ya gene ya MHC II n'indwara ya Parkinson.Igitangaje ni uko ubwoko bumwe butandukanye bugira ingaruka ku ndwara ya Parkinson mu buryo butandukanye muri Caucase / Abanyaburayi n'Abashinwa.Imirasire ya MHC II iratandukanye cyane kubantu;kubwibyo, bafite uruhare runini muguhitamo kwimura ingingo.
Ubundi bushakashatsi bwerekanye ko itandukaniro rishingiye ku ngirabuzima fatizo zifitanye isano n'indwara ya Parkinson rifitanye isano n'imikorere y'ingirabuzimafatizo.Abashakashatsi bagaragaje ko mu barwayi 81 ba Parkinson barwaye indwara ndetse n’ubugenzuzi bw’ibihugu by’i Burayi baturutse muri kaminuza ya Emory, ingirabuzimafatizo z’abantu bafite ibyago byinshi by’ingirabuzima fatizo za MHC II z’ubushakashatsi bwakozwe muri Californiya zerekanye molekile nyinshi za MHC.
Molekile ya MHC ishingiye kubikorwa bya "antigen presentation" kandi ni imbaraga zitera gukora selile T kandi igakora sisitemu yumubiri isigaye.Imvugo ya MHC II yiyongereye mu ngirabuzimafatizo zituje z’abarwayi ba Parkinson no kugenzura ubuzima bwiza, ariko igisubizo kinini ku kibazo cy’ubudahangarwa kigaragara ku barwayi b’indwara ya Parkinson bafite genotypes zifite ibyago byinshi;
Abanditsi banzuye bagira bati: “Amakuru yacu yerekana ko ibimenyetso bya biomarkers selile, nko gukora MHC II, bishobora kuba ingirakamaro kuruta molekile zishonga muri plasma na cerebrospinal fluid mu kumenya abantu bafite ibyago by’indwara cyangwa gushaka abarwayi kugira ngo bagire uruhare mu igeragezwa ry’imiti ikingira indwara.””Ikizamini.”
Ubushakashatsi bwatewe inkunga n'Ikigo cy'igihugu gishinzwe indwara z’imitsi n’ubwonko (R01NS072467, 1P50NS071669, F31NS081830), Ikigo cy’igihugu cy’ubumenyi bw’ubuzima bushingiye ku bidukikije (5P01ES016731), Ikigo cy’igihugu gishinzwe ubumenyi bw’ubuvuzi rusange (GM47310), Fondasiyo ya Sartain Lanier, na Fondasiyo ya Michael J. Foxpa Kingson ishinzwe ubushakashatsi ku ndwara.
Igihe cyo kohereza: Jun-04-2024