Guhura n'udukoko twa pyrethroids bishobora kongera ibyago byo kurwara indwara ya Parkinson bitewe n'uko duhura n'uturemangingo tw'umubiri binyuze mu budahangarwa bw'umubiri.
Pyrethroids ziboneka mu bucuruzi bwinshiimiti yica udukoko yo mu ngoNubwo zitera uburozi mu mitsi y'udukoko, muri rusange inzego za leta zifata ko zitekanye ku bantu.
Ihindagurika ry’uturemangingo n’imiti yica udukoko bisa nkaho bigira ingaruka ku kaga ko kurwara indwara ya Parkinson. Ubushakashatsi bushya bwagaragaje isano iri hagati y’ibi bintu bibiri bishobora gutera, bugaragaza uruhare rw’ubudahangarwa bw’umubiri mu iterambere ry’indwara.
Ibyavuye mu bushakashatsi bifitanye isano n'itsinda ryaimiti yica udukokoyitwa pyrethroids, iboneka mu miti myinshi yica udukoko yo mu ngo kandi ikoreshwa cyane mu buhinzi mu gihe indi miti yica udukoko igenda ikurwaho. Nubwo pyrethroids ari uburozi ku dukoko, abayobozi ba leta muri rusange babona ko ari nta kibazo cyo kwanduzwa n’abantu.
Ubu bushakashatsi ni bwo bwa mbere buhuza ubwiyongere bw’indwara ya pyrethroid n’ingaruka za genetiki ku ndwara ya Parkinson kandi busaba ko hakurikiraho ubushakashatsi, nk’uko byatangajwe n’umwanditsi mukuru Malu Tansi, Ph.D., umwarimu wungirije wa physiology muri Emory University School of Medicine.
Ubwoko bw'uturemangingo itsinda ryavumbuye buri mu gace katagaragaza ko ari kode y'uturemangingo twa MHC II (major histocompatibility complex class II), itsinda ry'uturemangingo tugenzura ubudahangarwa bw'umubiri.
Tansey yagize ati: “Ntitwiteze kubona isano yihariye n’udukoko twa pyrethroids. Birazwi ko kwibasirwa cyane n’udukoko twa pyrethroids bishobora gutera imikorere mibi y’ubudahangarwa bw’umubiri, kandi molekile zikoraho zishobora kuboneka mu turemangingo tw’ubudahangarwa bw’umubiri; Ubu dukeneye gusobanukirwa byinshi ku buryo kwibasirwa igihe kirekire bigira ingaruka ku budahangarwa bw’umubiri bityo bikanongera imikorere yabwo.” Ingaruka zo kurwara indwara ya Kinson.”
“Hari ibimenyetso bikomeye bigaragaza ko kubyimba mu bwonko cyangwa ubudahangarwa bw’umubiri bukora cyane bishobora kugira uruhare mu kwiyongera kw’indwara ya Parkinson. “Turatekereza ko ikiba kirimo kuba hano ari uko kwibasirwa n’ibidukikije bishobora guhindura uburyo ubudahangarwa bw’umubiri bukora ku bantu bamwe, bigatera ububyimbirwe budakira mu bwonko.”
Ku bw'ubu bushakashatsi, abashakashatsi ba Emory bayobowe na Tansey na Jeremy Boss, Ph.D., umuyobozi w'Ishami rya Microbiology na Immunology, bafatanyije na Stuart Factor, Ph.D., umuyobozi w'Ikigo cyita ku ndwara ya Parkinson cya Emory, na Beate Ritz., MD, Kaminuza ya California, San Francisco. Ku bufatanye n'abashakashatsi ku buzima rusange muri UCLA, Ph.D. Umwanditsi wa mbere w'iyi nkuru ni George T. Kannarkat, MD.
Abashakashatsi ba UCLA bakoresheje ububiko bw’amakuru bwa California bushingiye ku myaka 30 y’ikoreshwa ry’imiti yica udukoko mu buhinzi. Bagenzuye uburyo imiti yica udukoko ikwirakwira bitewe n’intera (aho umuntu akorera n’aho atuye) ariko ntibapimye urugero rw’imiti yica udukoko mu mubiri. Bivugwa ko pyrethroids igabanuka vuba cyane cyane iyo ishyizwe ku zuba, ikaba imara iminsi myinshi mu butaka, ikaba imara iminsi myinshi cyangwa ibyumweru.
Mu bantu 962 bakoreweho ubushakashatsi bo muri Kaliforuniya, ubwoko bwa MHC II busanzwe hamwe n’imiti yica udukoko iterwa na pyrethroid byongereye ibyago byo kurwara indwara ya Parkinson. Ubwoko bw’uturemangingo buteje akaga cyane (abantu bafite alleles ebyiri zishobora gutera ibyago) bwabonetse muri 21% by’abarwayi ba Parkinson na 16% by’abayirwanya.
Muri iri tsinda, kwandura gene cyangwa pyrethroid byonyine ntibyakongereye cyane ibyago byo kurwara indwara ya Parkinson, ariko uruvange rwabyo rwakongereye. Ugereranije n'impuzandengo, abantu bahuye n'udukoko twa pyrethroid kandi bafite ubwoko bwinshi bw'akaga ka MHC II bari bafite ibyago bikubye inshuro 2.48 byo kurwara indwara ya Parkinson kurusha abahura n'akaga gake kandi bafite ubwoko buke bw'akaga ka gene. Kwandura ubundi bwoko bw'imiti yica udukoko, nka organophosphates cyangwa paraquat, ntabwo byongera ibyago mu buryo bumwe.
Ubushakashatsi bunini bwakozwe ku ngirabuzimafatizo, harimo na Factor n'abarwayi be, bwabanje guhuza ihinduka rya gene ya MHC II n'indwara ya Parkinson. Igitangaje ni uko iryo hinduka rya gene rigira ingaruka zitandukanye ku byago byo kurwara Parkinson ku Banya-Caucasian/Abanyaburayi n'Abashinwa. Ingirabuzimafatizo za MHC II ziratandukanye cyane hagati y'abantu; bityo, zigira uruhare runini mu guhitamo uburyo bwo gutera ingingo.
Andi magerageza yagaragaje ko itandukaniro ry’uturemangingo rijyanye n’indwara ya Parkinson rifitanye isano n’imikorere y’uturemangingo tw’umubiri. Abashakashatsi basanze mu barwayi 81 ba Parkinson n’abashinzwe kugenzura i Burayi bo muri Kaminuza ya Emory, uturemangingo tw’umubiri tw’abantu bafite ubwoko bw’uturemangingo twa MHC II dushobora kuba dufite ibyago byinshi byo kwanduzwa n’ubushakashatsi bwa California bwagaragaje uturemangingo twinshi twa MHC.
Molekile za MHC ni zo zigize uruhare mu "kwigaragaza kwa antigen" kandi ni zo zitera imbaraga uturemangingo twa T kandi zigakoresha ubudahangarwa bw'umubiri busigaye. Igaragara rya MHC II ririyongera mu turemangingo dutuje tw'abarwayi ba Parkinson n'abashinzwe kurwanya indwara z'umutima, ariko uburyo bwo guhangana n'ikibazo cy'ubudahangarwa bw'umubiri bugaragara ku barwayi ba Parkinson bafite ubwoko bw'uturemangingo tw'umubiri dufite ibyago byinshi;
Abanditsi basoje bagira bati: “Amakuru yacu agaragaza ko ibimenyetso by’uturemangingo, nka MHC II activation, bishobora kuba ingirakamaro kurusha molekile zishobora gushonga muri plasma no mu mazi yo mu bwonko mu kumenya abantu bashobora kurwara cyangwa mu gushaka abarwayi kwitabira igeragezwa ry’imiti igabanya ubudahangarwa bw’umubiri.”
Ubu bushakashatsi bwatewe inkunga n'Ikigo cy'Igihugu cyita ku ndwara z'imitsi n'imitsi yo mu bwonko (R01NS072467, 1P50NS071669, F31NS081830), Ikigo cy'Igihugu cy'Ubumenyi bw'Ubuzima bushingiye ku Bidukikije (5P01ES016731), Ikigo cy'Igihugu cy'Ubumenyi rusange bw'Ubuvuzi (GM47310), Umuryango wa Sartain Lanier, n'Ikigo cya Michael J. Foxpa Kingson cyita ku Bushakashatsi ku Bidukikije.
Igihe cyo kohereza: Kamena-04-2024