Ingaruka za IRS ukoresheje pirimiphos-methyl ku kwandura malariya no kugaragara mu rwego rwo kurwanya pyrethroide mu Karere ka Koulikoro, Ikinyamakuru Malariya Ikinyamakuru Malariya |

Umubare rusange w’abana banduye kuva ku mezi 6 kugeza ku myaka 10 wari 2.7 ku mezi 100 y’amezi 100 mu karere ka IRS na 6.8 ku mezi 100 y’umuntu mu karere kayobora. Ariko, nta tandukaniro rikomeye ryagaragaye muri malariya hagati yibi bibanza mu mezi abiri yambere (Nyakanga - Kanama) na nyuma yimvura (Ukuboza - Gashyantare) (reba Ishusho 4).
Kaplan-Meier kurokoka kubana bafite hagati yimyaka 1 na 10 mukarere k’inyigisho nyuma y'amezi 8 yo gukurikirana
Ubu bushakashatsi bwagereranije ubwiyongere bwa malariya n'indwara mu turere tubiri dukoresheje ingamba zihamye zo kurwanya malariya kugira ngo hamenyekane ingaruka z’imisoro n'amahoro. Amakuru yakusanyirijwe mu turere tubiri binyuze mu bushakashatsi bubiri bwambukiranya ibice ndetse n’amezi 9 y’ubushakashatsi bwakozwe mu mavuriro y’ubuzima. Ibisubizo bivuye mu bushakashatsi bwakozwe mu ntangiriro no mu mpera z’igihe cyo kwandura malariya byerekanye ko malariya parasitaemia yari hasi cyane mu karere ka IRS (LLTID + IRS) kuruta mu karere kagenzura (LLTIN gusa). Kubera ko uturere twombi tugereranywa kubijyanye na malariya epidemiologiya no gutabara, iri tandukaniro rishobora gusobanurwa n’agaciro kongerewe imisoro mu karere ka IRS. Mubyukuri, byombi inshundura zica udukoko hamwe na IRS bizwiho kugabanya cyane umutwaro wa malariya iyo ukoreshejwe wenyine. Niyo mpamvu, ubushakashatsi bwinshi [7, 21, 23, 24, 25] buteganya ko guhuza kwabo bizatuma kugabanuka kwa malariya kugabanuka cyane kuruta bonyine. Nubwo IRS, Plasmodium parasitaemia yiyongera kuva mu ntangiriro kugeza mu mpera z’igihe cy’imvura mu turere twanduye malariya, kandi biteganijwe ko iyi mvura izagera ku gihe cy’imvura irangiye. Nyamara, kwiyongera mu karere ka IRS (53.0%) kwaragabanutse cyane ugereranije n’ahantu hagenzurwa (220.0%). Imyaka icyenda ikurikirana ubukangurambaga bwa IRS nta gushidikanya ko yafashije kugabanya cyangwa guhagarika impinga zo kwanduza virusi mu turere twa IRS. Byongeye kandi, nta tandukanyirizo ryerekanwe rya gametophyte hagati yibice byombi mugitangira. Igihe cy'imvura kirangiye, cyari hejuru cyane mugenzuzi (11.5%) ugereranije no muri IRS (3.2%). Iri genzura risobanura igice gito cyanduye malariya parasitemiya mu karere ka IRS, kubera ko igipimo cya gametocyte ari isoko y’indwara y’imibu itera kwandura malariya.
Ibisubizo by'isesengura ry’ibisubizo byerekana ingaruka nyazo ziterwa no kwandura malariya mu gace kayobora kandi bikagaragaza ko isano iri hagati y’umuriro na parasitemiya ikabije kandi ko kubura amaraso ari ibintu bitera urujijo.
Kimwe na parasitaemia, indwara ya malariya mu bana bafite hagati y’imyaka 0-10 yari hasi cyane muri IRS ugereranije no kugenzura. Impinga zo kwanduza gakondo zagaragaye muri utwo turere twombi, ariko zari hasi cyane muri IRS ugereranije no kugenzura (Ishusho 3). Mubyukuri, mugihe imiti yica udukoko imara hafi imyaka 3 muri LLINs, imara amezi agera kuri 6 muri IRS. Kubwibyo, ubukangurambaga bwa IRS bukorwa buri mwaka kugirango habeho impanuka zoherejwe. Nkuko bigaragazwa nu murongo wo kurokoka wa Kaplan - Meier (Igicapo 4), abana baba mu turere twa IRS barwaye indwara nkeya ya malariya kurusha abo mu turere twigenzura. Ibi bihuye nubundi bushakashatsi bwerekanye ko igabanuka rikabije ry’indwara ya malariya iyo yaguye IRS ihujwe n’ibindi bikorwa. Nyamara, igihe ntarengwa cyo kurinda ingaruka zisigaye za IRS cyerekana ko iyi ngamba ishobora gukenera kunozwa hakoreshejwe imiti yica udukoko igihe kirekire cyangwa kongera inshuro yo kuyikoresha.
Itandukaniro mu bwiganze bw'amaraso make hagati ya IRS n'ahantu hagenzurwa, hagati yimyaka itandukanye no hagati yabitabiriye bafite umuriro kandi nta muriro ushobora kuba nk'ikimenyetso cyiza kitaziguye cyerekana ingamba zikoreshwa.
Ubu bushakashatsi bwerekana ko IRS ya pirimiphos-methyl IRS ishobora kugabanya cyane ubwandu bwa malariya ku bana bari munsi y’imyaka 10 mu karere ka Koulikoro irwanya pyrethroide, kandi ko abana baba mu turere twa IRS bakunze kwandura malariya kandi bagakomeza kutagira malariya. kirekire mu karere. Ubushakashatsi bwerekanye ko pirimiphos-methyl ari umuti wica udukoko two kurwanya malariya mu turere dukunze kurwanya pyrethide.