Acide 5-aminolevuline igenzura ikura ry’ibimera by’inyanya yongera ubukonje bw’ibimera.

      Nk'imwe mu mpamvu zikomeye zituma ibimera birushaho kuba bibi, ubushyuhe buke bubangamira cyane imikurire y'ibimera kandi bukagira ingaruka mbi ku musaruro n'ubwiza bw'ibihingwa. Aside 5-Aminolevuline (ALA) ni umuyoboro w'imikurire iboneka cyane mu nyamaswa n'ibimera. Kubera ko ikora neza cyane, idahumanya kandi yoroshye kwangiza, ikoreshwa cyane mu kwihanganira ubukonje bw'ibimera.
Ariko, ubushakashatsi bwinshi bugezweho bujyanye na ALA bwibanda cyane cyane ku kugenzura iherezo ry'urusobe rw'ibinyabuzima. Uburyo bwihariye bw'imikorere ya ALA mu kwihanganira ubukonje bw'ibimera ntabwo burasobanuka neza kandi busaba ubushakashatsi bw'inyongera bukorwa n'abahanga mu bya siyansi.
Muri Mutarama 2024, Ubushakashatsi ku buhinzi bwasohoye inyandiko y’ubushakashatsi yitwa “5-Aside Aminolevuline Yongera Ubushobozi bwo Kwihanganira Ubukonje binyuze mu Kugenzura Uburyo bwo Gusarura Ubwoko bwa Ogisijeni mu Nyanya bwa SlMYB4/SlMYB88-SlGSTU43” yakozwe n’itsinda rya Hu Xiaohui muri Kaminuza ya Northwestern y’ubuhinzi n’amashyamba.
Muri ubu bushakashatsi, gene ya glutathione S-transferase SlGSTU43 yagaragaye mu nyanya (Solanum lycopersicum L.). Ibisubizo by'ubushakashatsi byagaragaje ko ALA itera cyane SlGSTU43 gukora iyo umuntu arwaye mu gihe cy'ubukonje. Imiterere y'inyanya ya transgenic SlGSTU43 yagaragaje ubushobozi bwo gukuraho ogisijeni mu bwoko bwayo kandi yagaragaje ubudahangarwa bukomeye ku bushyuhe buke, mu gihe imiterere ya SlGSTU43 yashoboraga kwihanganira ubushyuhe buke.
Byongeye kandi, ibyavuye mu bushakashatsi byagaragaje ko ALA idatuma ubwoko bwa mutant bushobora kwihanganira ubushyuhe buke. Bityo, ubushakashatsi bwerekana ko SlGSTU43 ari gene y'ingenzi mu kongera ubushobozi bwo kwihanganira ubukonje bw'inyanya na ALA (Ishusho ya 1).
Byongeye kandi, ubu bushakashatsi bwemeje binyuze mu gusuzuma EMSA, Y1H, LUC na ChIP-qPCR ko SlMYB4 na SlMYB88 bishobora kugenzura igaragara rya SlGSTU43 binyuze mu guhuza na promoter ya SlGSTU43. Ibindi bipimo byagaragaje ko SlMYB4 na SlMYB88 nabyo bigira uruhare muri gahunda ya ALC binyuze mu kongera ubushobozi bwo kwihanganira inyanya kugeza ku bushyuhe buke no kugenzura neza igaragara rya SlGSTU43 (Ishusho ya 2). Ibi bisubizo bitanga ibisobanuro bishya ku buryo ALA yongera ubushobozi bwo kwihanganira ubushyuhe buke mu nyanya.
Amakuru arambuye: Zhengda Zhang n'abandi, aside 5-aminolevuline yongera ubushobozi bwo kwihanganira ubukonje binyuze mu kugenzura module ya SlMYB4/SlMYB88-SlGSTU43 ku bwoko bwa ogisijeni bukoreshwa mu gusarura inyanya, Ubushakashatsi ku buhinzi (2024). DOI: 10.1093/isaha/uhae026
Niba uhuye n'ikosa ry'ikosa, amakosa, cyangwa wifuza gutanga icyifuzo cyo guhindura ibikubiye kuri uru rupapuro, nyamuneka koresha iyi fomu. Ku bibazo rusange, nyamuneka koresha fomu yacu yo kutwandikira. Ku bitekerezo rusange, nyamuneka koresha igice cy'ibitekerezo rusange kiri hepfo (kurikiza amabwiriza).
Ibitekerezo byanyu ni ingenzi cyane kuri twe. Ariko, kubera ubwinshi bw'ubutumwa, ntabwo dushobora kwemeza igisubizo cyihariye.
Aderesi imeri yawe ikoreshwa gusa mu kubwira abayoherereje imeri. Aderesi yawe cyangwa aderesi y'uwayohererejwe nta kindi kizakoreshwa. Amakuru wanditse azagaragara muri imeri yawe kandi ntazabikwa na Phys.org mu buryo ubwo aribwo bwose.
Akira amakuru mashya ya buri cyumweru cyangwa ya buri munsi mu gasanduku kawe k'ubutumwa. Ushobora kwiyambura igihe icyo ari cyo cyose kandi ntabwo tuzasangiza amakuru yawe abandi bantu.
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