Florfenicol, intungamubiri ya monofluorine ikomoka kuri thiamphenicol, ni imiti mishya ya antibacterial antibacterial ya chloramphenicol yo gukoresha amatungo, yakozwe neza mu mpera za 1980.
Ku bijyanye n'indwara zikunze kubaho, imirima myinshi y'ingurube ikoresha florfenicol kenshi kugirango ikingire cyangwa ivure indwara z'ingurube. Nubwo indwara yaba imeze ite, niyo itsinda cyangwa icyiciro, abahinzi bamwe bakoresha super-dose ya florfenicol mu kuvura cyangwa gukumira indwara. Florfenicol ntabwo ari umuti. Igomba gukoreshwa neza kugirango igere ku ngaruka zifuzwa. Ibikurikira nintangiriro irambuye kumyumvire isanzwe yo gukoresha florfenicol, twizeye gufasha abantu bose:
1. Antibacterial properties of florfenicol
. Bagiteri ziyumva zirimo bovine na porcine Haemophilus, Shigella dysenteriae, Salmonella, Escherichia coli, Pneumococcus, ibicurane bacillus, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, nibindi byiza.
.
. kumara igihe kinini, ibiyobyabwenge byamaraso bishobora gukomeza amasaha arenga 20 nyuma yubuyobozi bumwe.
.
. Ikoreshwa mu kwanduza ibice bitandukanye byumubiri biterwa na bagiteri mu nyamaswa. Kuvura ingurube, harimo gukumira no kuvura indwara z'ubuhumekero za bagiteri, meningite, pleurisy, mastitis, indwara zo mu nda na syndrome ya nyuma yo kubyara mu ngurube.
2. Indwara ya bagiteri yanduye ya florfenicol hamwe nindwara yingurube ya florfenicol
(1) Indwara z'ingurube aho florfenicol ikundwa
Iki gicuruzwa kirasabwa nk'umuti uhitamo umusonga w'ingurube, porcine yanduye pleuropneumonia n'indwara ya Haemophilus parasuis, cyane cyane mu kuvura bagiteri zirwanya fluoroquinolone n'izindi antibiyotike.
(2) Florfenicol irashobora kandi gukoreshwa mukuvura indwara zingurube zikurikira
Irashobora kandi gukoreshwa mu kuvura indwara z'ubuhumekero ziterwa na Streptococcus zitandukanye (pneumoniya), Bordetella bronchiseptica (rinite atrophique), Mycoplasma pneumoniae (asima y'ingurube), n'ibindi.; salmonellose (piglet paratyphoid), colibacillose (asima y'ingurube) Indwara zifata igifu nka enterite iterwa n'impiswi z'umuhondo, impiswi zera, indwara y'ingurube) n'izindi bagiteri zoroshye. Florfenicol irashobora gukoreshwa mu kuvura izo ndwara z'ingurube, ariko ntabwo ariwo muti uhitamo izo ndwara z'ingurube, bityo ugomba gukoreshwa witonze.
3. Gukoresha nabi florfenicol
(1) Igipimo ni kinini cyane cyangwa gito cyane. Ingano zimwe zo kugaburira zivanze zigera kuri 400 mg / kg, naho inshinge zigera kuri 40-100 mg / kg, cyangwa hejuru. Bimwe ni bito nka 8 ~ 15mg / kg. Ingano nini ni uburozi, kandi dosiye ntoya ntacyo ikora.
(2) Igihe ni kirekire cyane. Bimwe murigihe kirekire gukoresha ibiyobyabwenge byinshi nta kubuza.
(3) Gukoresha ibintu nibyiciro ni bibi. Kubiba inda n'ingurube zibyibushye zikoresha ibiyobyabwenge mu buryo butarobanuye, bigatera uburozi cyangwa ibisigazwa byibiyobyabwenge, bikavamo umusaruro muke ndetse nibiribwa.
(4) Guhuza bidakwiye. Abantu bamwe bakunze gukoresha florfenicol hamwe na sulfonamide na cephalosporine. Niba ari siyanse kandi yumvikana birakwiye gushakisha.
.
4. Gukoresha ingamba zo kwirinda florfenicol
. iyo bihujwe bishobora kubyara ingaruka zo kurwanya.
. , icya nyuma ni bactericide ikora vuba mugihe cyo kororoka. Mubikorwa byabanje, synthesis ya bagiteri ya protein ihagarikwa byihuse, bagiteri ihagarika gukura no kugwira, kandi ingaruka za bagiteri ziterwa na nyuma ziracika intege. Kubwibyo, mugihe ubuvuzi bukeneye kugira ingaruka zihuse zo kuboneza urubyaro, ntibushobora gukoreshwa hamwe.
(3) Iki gicuruzwa ntigishobora kuvangwa na sodium ya sulfadiazine yo gutera inshinge. Ntigomba gukoreshwa ifatanije nibiyobyabwenge bya alkaline mugihe itanzwe kumunwa cyangwa mumitsi, kugirango wirinde kubora no gutsindwa. Ntibikwiye kandi gutera inshinge hamwe na tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, nibindi, kugirango wirinde kugwa no kugabanuka kwingirakamaro.
(4) Kwangirika kw'imitsi na necrosis birashobora guterwa nyuma yo gutera inshinge. Kubwibyo, irashobora guterwa ubundi buryo mumitsi yimbitse yijosi nigituba, kandi ntabwo ari byiza gusubiramo inshinge kurubuga rumwe.
(5) Kubera ko iki gicuruzwa gishobora kuba gifite intanga ngore, kigomba gukoreshwa ubwitonzi mu mbuto zitwite kandi zonsa.
.
. Birakwiye, kuko duhereye kuri farumasi, byombi ntibishobora gukoreshwa hamwe. Nyamara, florfenicol irashobora gukoreshwa hamwe na tetracycline nka doxycycline.
(8) Iki gicuruzwa gifite uburozi bwa hematologiya. Nubwo bitazatera amagufa adasubirwaho amaraso aplastique anemia, guhagarika bidasubirwaho erythropoiesis iterwa nayo birasanzwe kuruta ibya chloramphenicol (ubumuga). Yandujwe mugihe cyo gukingira cyangwa inyamaswa zifite ubudahangarwa bukabije.
(9) Gukoresha igihe kirekire birashobora gutera ikibazo cyigifu no kubura vitamine cyangwa ibimenyetso bya superinfection.
.
(11) Ku nyamaswa zifite impyiko zidahagije, igipimo kigomba kugabanuka cyangwa intera yubuyobozi igomba kongerwa.
(12) Mugihe cy'ubushyuhe buke, usanga igipimo cyo gusesa gitinda; cyangwa igisubizo cyateguwe gifite imvura ya florfenicol, kandi igomba gushyuha gusa (itarenze 45 ℃) kugirango ishonga vuba. Igisubizo cyateguwe gikoreshwa neza mumasaha 48.
Igihe cyo kohereza: Kanama-09-2022