Umuti wo mu rwego rwo hejuru w’imiti y’amatungo witwa Florfenicol CAS 73231-34-2
Florfenicol ni umuti ukoreshwa cyane mu matungo ufite uburyo bwinshi bwo kurwanya indwara zandura, ufite ubushobozi bwo kurwanya indwara zandura, ufite ubushobozi bwo kwirinda indwara zandura, ufite ubushobozi buke bwo kwirinda indwara (MIC), ufite umutekano mwinshi, nta burozi, kandi nta bisigazwa byawo. Nta ngaruka zishobora gutera indwara ya aplastic anemia kandi ikwiriye ubworozi bunini bw’amatungo. Ikoreshwa cyane cyane mu kuvura indwara z’ubuhumekero bw’inka ziterwa na bagiteri za Pasteurella na Haemophilus. Ifite ingaruka nziza ku kuvura indwara zo mu bwonko ziterwa na Clostridium. Ikoreshwa kandi ku ndwara zandura ziterwa na bagiteri zikomeye mu ngurube n’inkoko, ndetse n’indwara za bagiteri mu mafi.
Ikimenyetso
1. Amatungo: mu rwego rwo gukumira no kuvura asima y'ingurube, indwara ya pleuropneumonia yandura, rhinitis itera atrophic, indwara y'ibihaha by'ingurube, indwara ya streptococcal iterwa no guhumeka nabi, kwiyongera k'ubushyuhe, inkorora, kubyimba, kugabanuka kw'ibiryo, gutakaza imbaraga, nibindi, bigira ingaruka zikomeye kuri E. coli n'izindi mpamvu zitera impiswi y'umuhondo n'umweru y'ingurube, enteritis, impiswi y'amaraso, indwara yo kubyimba n'ibindi.
2. Inkoko: mu rwego rwo gukumira no kuvura inkoko ziterwa na E. coli, Salmonella, Pasteurella n'izindi kolera, impiswi y'inkoko y'umweru, impiswi, impiswi idakira, umwanda w'icyatsi cy'umuhondo, umwanda w'amazi, impiswi, amaraso mu mara, omphalitis, pericardium, umwijima, bagiteri, mycoplasma iterwa n'indwara z'ubuhumekero zidakira, rhinitis yandura, turbidity y'inyuma, inkorora, trachea rales, nibindi.
3. Igira ingaruka zigaragara ku ndwara yandura ya serositite, Escherichia coli na Pseudomonas aeruginosa mu bishuhe.
4. Ku bikomoka mu mazi. Kuvura indwara y'amafi ya bagiteri, bifatwa mu mubiri.
Igipimo: 10-15mg/kg (ugereranyije n'uburemere bw'amafi), kabiri ku munsi (uyu muti uratera imbaraga, ugabanyijemo kabiri), muri rusange iminsi itatu mu gihe cy'ubuvuzi. Isambaza n'ibikara bigira amara magufi. Kubiri ingano. Icyitonderwa: Koresha ku minsi y'izuba.
Flufenicol irahuye n'ibyo
1. Iyo bivanze na neomycin, doxycycline hydrochloride, colistin sulfate, loricin, nibindi, ingaruka zo kuvura ziyongera.
2. Iyo bivanze na ampicillin, cefradine, cephalexin, nibindi, imikorere iragabanuka.
3. Kuba imiti ikoreshwa na kanamycin, streptomycin, sulfonamides na quinolones byongera uburozi.
4. Ihuye na VB12, ishobora gukumira erythropoiesis.
Ingaruka z'imiti
Ishobora gukwirakwizwa mu turemangingo twa bagiteri binyuze mu gushonga kw'ibinure, ahanini ikora ku gice cy'imyaka ya za 50 cya ribosome ya bagiteri yo mu myaka ya za 70, ikabuza transpeptidase, ikabuza gukura kwa peptidase, ikabuza ikorwa rya peptide chain, bityo ikabuza poroteyine gukora kugira ngo igere ku ntego zo kurwanya bagiteri. Iki gicuruzwa gifite imiterere myinshi ya bagiteri kandi kigira ingaruka zikomeye kuri bagiteri za Gram-positive na Gram-negative na mycoplasma. Iki gicuruzwa gishobora kwinjiza vuba mu kanwa, gukwirakwira cyane, kumara igihe kirekire, kuba kinini mu maraso no gukomeza gukoresha imiti mu maraso igihe kirekire.
