Hamwe n’umusaruro wa toni zirenga 700.000, glyphosate ni yo ikoreshwa cyane kandi yica ibyatsi byinshi ku isi.Kurwanya nyakatsi hamwe n’ibishobora guhungabanya ibidukikije n’ubuzima bw’abantu biterwa no gukoresha glyphosate byitabiriwe cyane.
Ku ya 29 Gicurasi, itsinda rya Porofeseri Guo Ruiting ryaturutse muri Laboratwari nkuru ya Leta ya Biocatalysis na Enzyme Engineering, ryashinzwe n’ishuri ry’ubuzima bwa kaminuza ya Hubei n’ishami ry’intara na minisitiri, ryasohoye inyandiko y’ubushakashatsi iheruka gusohoka mu kinyamakuru cy’ibikoresho byangiza, isesengura isesengura ryambere ryibyatsi bya barnyard..
Gukura glyphosate.
Kuva yatangizwa mu myaka ya za 70, glyphosate yamenyekanye cyane ku isi yose, kandi buhoro buhoro yabaye iyihendutse cyane, ikoreshwa cyane kandi itanga umusaruro mwinshi wa herbicide.Itera indwara ziterwa no guhindagurika mu bimera, harimo n’ibyatsi, mu guhagarika cyane cyane 5-enolpyruvylshikimate-3-fosifate synthase (EPSPS), enzyme yingenzi igira uruhare mu mikurire y’ibimera no guhindagurika.n'urupfu.
Kubwibyo, korora ibihingwa byangiza glyphosate no gukoresha glyphosate mu murima ni inzira yingenzi yo kurwanya nyakatsi mu buhinzi bugezweho.
Nyamara, hamwe no gukoresha no gukoresha nabi glyphosate, ibyatsi bibi byinshi byahindutse buhoro buhoro kandi biteza imbere kwihanganira glyphosate.
Byongeye kandi, ibihingwa byahinduwe na glyphosate ntibishobora kubora glyphosate, bigatuma habaho kwegeranya no guhererekanya glyphosate mu bihingwa, bishobora gukwirakwira mu buryo bworoshye binyuze mu biribwa kandi bikangiza ubuzima bw’abantu.
Niyo mpamvu, byihutirwa kuvumbura ingirabuzimafatizo zishobora kwangiza glyphosate, kugirango duhinge ibihingwa byinshi byitwa glyphosate birwanya ibihingwa bya transgenji hamwe n’ibisigazwa bya glyphosate.
Gukemura imiterere ya kristu hamwe nuburyo bwa catalitiki yuburyo bwimiti ikomoka kuri glyphosate-yangiza
Mu mwaka wa 2019, amatsinda y’ubushakashatsi mu Bushinwa na Ositaraliya yerekanye glyphosate-itesha agaciro aldo-keto reductase, AKR4C16 na AKR4C17, ku nshuro ya mbere ivuye mu byatsi bya barnyard birwanya glyphosate.Bashobora gukoresha NADP + nka cofactor kugirango bagabanye glyphosate kuri aside aminomethylphosphonic nontoxic na aside glyoxylic.
AKR4C16 na AKR4C17 nizo misemburo ya mbere ivugwa ya glyphosate-itesha agaciro ikomoka ku ihindagurika ry’ibimera.Mu rwego rwo kurushaho gucukumbura uburyo bwa molekulike yo kwangirika kwa glyphosate, itsinda rya Guo Ruiting ryakoresheje X-ray kristu yerekana isesengura riri hagati yiyi misemburo yombi na cofactor ndende.Imiterere igoye yicyemezo yerekanye uburyo bwo guhuza urwego rwa ternary complex ya glyphosate, NADP + na AKR4C17, inasaba uburyo bwa catalitiki reaction ya AKR4C16 na AKR4C17 yunganirwa na glyphosate.
Imiterere ya AKR4C17 / NADP + / glyphosate igizwe nuburyo bwo kubyitwaramo bwa glyphosate.
Guhindura molekuline biteza imbere imikorere ya glyphosate.
Nyuma yo kubona icyitegererezo cyiza cyuburyo butatu bwa AKR4C17 / NADP + / glyphosate, itsinda rya Porofeseri Guo Ruiting ryongeye kubona poroteyine AKR4C17F291D yiyongereyeho 70% byangiza imikorere ya glyphosate ikoresheje isesengura ryimiterere ya enzyme no gushushanya neza.
Isesengura ryibikorwa bya glyphosate-bitesha agaciro AKR4C17 mutant.
Ati: "Ibikorwa byacu bigaragaza uburyo bwa molekuline ya AKR4C16 na AKR4C17 butera kwangirika kwa glyphosate, itanga umusingi w'ingenzi wo kurushaho guhindura AKR4C16 na AKR4C17 kugira ngo barusheho kunoza imikorere ya glyphosate."Umwanditsi wungirije w’uru rupapuro, Umwarimu wungirije Dai Longhai wo muri kaminuza ya Hubei Yavuze ko bubatse poroteyine AKR4C17F291D ifite uburyo bwiza bwo kwangirika kwa glyphosate, itanga igikoresho cy’ingenzi mu guhinga ibihingwa byinshi byangiza glyphosate hamwe n’ibisigazwa bya glyphosate ndetse no gukoresha za bagiteri za mikorobe. gutesha agaciro glyphosate mubidukikije.
Biravugwa ko itsinda rya Guo Ruiting rimaze igihe kinini mu bushakashatsi ku isesengura ry’imiterere n’uburyo bwo kuganira ku misemburo ya biodegradation, synthase ya terpenoid, hamwe na poroteyine zigamije kurwanya ibiyobyabwenge byangiza kandi byangiza ibidukikije.Li Hao, umushakashatsi wungirije Yang Yu hamwe n’umwarimu Hu Yumei muri iryo tsinda ni abanditsi ba mbere banditse impapuro, naho Guo Ruiting na Dai Longhai ni abanditsi bahuje.
Igihe cyo kohereza: Jun-02-2022