Florfenikolni umuti urwanya udukoko twinshi, ufite ingaruka nziza zo gukumira bagiteri za Gram-positive na bagiteri mbi. Kubwibyo, ubworozi bwinshi bw'ingurube bukunze gukoresha florfenicol mu gukumira cyangwa kuvura ingurube mu gihe zirwaye indwara zikunze kugaragara. Abaganga b'amatungo bo mu mashyo amwe n'amwe y'ingurube bakoresha doze nini ya florfenicol mu kuvura cyangwa gukumira indwara hatitawe ku ndwara, hatitawe ku itsinda cyangwa icyiciro. Florfenicol si umuti w'indwara, kandi igomba gukoreshwa neza kugira ngo igere ku ngaruka zifuzwa. Hasi turagaragaza uburyo bwo gukoresha florfenicol mu buryo burambuye, twizeye ko izafasha benshi mu borozi b'ingurube:
1. Imiterere y'imiti irwanya bagiteriflorfenikoli
1. Ifite ubwoko bwinshi cyane bwa bagiteri zirwanya indwara, kandi igira ingaruka zikomeye ku bagiteri za Gram-positive na bagiteri mbi, ndetse na bagiteri za Gram-positive na spirochetes mbi zidafite umwuka, rickettsia, amibe, n'izindi. Ingaruka zikomeye ku bagiteri zirwanya indwara.
2. Igerageza ryakozwe muri vitro na vivo ryerekana ko imikorere yaryo ya antibacterial ari myiza cyane kurusha imiti ikoreshwa muri iki gihe.
3. Florfenicol ikora vuba ishobora kugera ku rugero rwo kuvura mu maraso isaha 1 nyuma yo guterwa inshinge mu mitsi, kandi urugero rw'umuti rushobora kugerwaho mu masaha 1.5-3; urugero rw'umuti mu maraso rumara igihe kirekire kandi rufite akamaro rushobora kugumaho mu gihe kirenze amasaha 20 nyuma yo guterwa rimwe.
4. Ishobora kwinjira mu ruzitiro rw'amaraso n'ubwonko, kandi ingaruka zayo ku ndwara ya meningite iterwa na bagiteri y'amatungo ntagereranywa n'indi miti irwanya bagiteri.
5. Nta burozi cyangwa ingaruka mbi igira iyo ikoreshejwe ku gipimo cyagenwe, irwanya akaga ko kubura amaraso mu mubiri (aplastic anemia) n'ubundi burozi buterwa na thiamphenicol, kandi ntigira ingaruka mbi ku matungo no ku biribwa. Ikoreshwa mu kwandura ibice bitandukanye by'umubiri biterwa na bagiteri mu matungo. Kuvura, harimo gukumira no kuvura indwara z'ubuhumekero za bagiteri, meningitis, pleurisy, mastite, indwara zo mu mara n'indwara zo nyuma yo kubyara mu ngurube.
2. Bagiteri zishobora kwanduraflorfenikoli
1. Indwara z'ingurube aho florfenicol ari yo ikundwa cyane
Uyu muti usabwa nk'umuti ukoreshwa cyane mu kuvura indwara ya pneumonia y'ingurube, pleuropneumonia yandurira mu biguruka n'indwara ya Haemophilus parasuis, cyane cyane mu kuvura bagiteri zirwanya fluoroquinolones n'izindi antibiyotike.
2. Florfenicol ishobora kandi gukoreshwa mu kuvura indwara z'ingurube zikurikira
Ishobora kandi gukoreshwa mu kuvura indwara z'ubuhumekero ziterwa na Streptococcus (pneumonia), Bordetella bronchiseptica (atrophic rhinitis), Mycoplasma pneumoniae (asthma y'ingurube), n'ibindi; salmonellosis (piglet paratyphoid), colibacillosis (asthma y'ingurube) Indwara zo mu gifu nka enteritis iterwa n'impiswi y'umuhondo, impiswi y'umweru, indwara yo kwishima kw'ingurube) n'izindi bagiteri zikomeye. Florfenicol ishobora gukoreshwa mu kuvura izi ndwara z'ingurube, ariko si wo muti ukoreshwa cyane kuri izi ndwara z'ingurube, bityo igomba gukoreshwa witonze.
3. Gukoresha nabiflorfenikoli
1. Igipimo ni kinini cyane cyangwa gito cyane. Igipimo kinini ni uburozi, naho igipimo gito ntigitanga umusaruro.Ese?
2. igihe ni kirekire cyane. Gukoresha imiti myinshi igihe kirekire nta mbogamizi.
3.gukoresha ibintu, amakosa yo mu cyiciro. Ingurube zitwite n'ingurube zibyibushye zikoresha iyo miti mu buryo butari bwo, bigatera uburozi cyangwa ibisigazwa by'imiti, bigatera umusaruro n'ibiribwa bidafite umutekano.
4. Kuba umuti uhuye nabi. Hari abantu bakunze gukoresha florfenicol hamwe na sulfonamides na cephalosporins. Niba ari siyansi kandi bifite ishingiro, birakwiye gukorerwa ubushakashatsi.
5. Kurya bivanze ntibivangwa neza, bigatuma nta ngaruka z'umuti cyangwa uburozi bw'ibiyobyabwenge bitera.
Icya kane, ikoreshwa ryaflorfenikoliingamba zo kwirinda
1. Uyu muti ntugomba gukoreshwa hamwe na macrolides, lincosamides na diterpenoid semi-synthetic antibiotics - Tiamulin, ishobora kugira ingaruka mbi iyo ikoreshejwe hamwe.Ese?
2. Iki gicuruzwa ntigishobora gukoreshwa hamwe naβ-amine za lactone na fluoroquinolones, kuko uyu muti ari umuti utuma bagiteri ikora vuba ubuza poroteyine ya bagiteri, naho uwa nyuma ukaba umuti utuma bagiteri ikora vuba mu gihe cyo kubyara. Mu gihe cy'ibikorwa bya wa mbere, poroteyine ya bagiteri irahagarikwa vuba, bagiteri zihagarika gukura no kwiyongera, kandi ingaruka zo kwica bagiteri za wa nyuma ziragabanuka. Kubwibyo, iyo ubuvuzi bukeneye kugira ingaruka zo gufunga vuba, ntibushobora gukoreshwa hamwe.
3. Uyu muti ntushobora kuvangwa na sulfadiazine sodium mu gutera imiti mu mitsi. Ntugomba gukoreshwa hamwe n'imiti ya alkaline iyo unyowe cyangwa uterwa mu mitsi, kugira ngo wirinde kubora no gutsindwa. Ntabwo kandi ukwiriye guterwa mu mitsi na tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, nibindi, kugira ngo wirinde ko amazi agwa kandi imikorere ikagabanuka.
4. Kwangirika kw'imitsi no kwangirika kw'imitsi bishobora guterwa nyuma yo guterwa inshinge mu mitsi. Kubwibyo, ishobora guterwa mu mitsi yo mu ijosi no mu matako mu buryo bunyuranye, kandi si byiza kongera guterwa inshinge ahantu hamwe.
5. Kubera ko uyu muti ushobora kugira uburozi mu nda y'umwana, ugomba gukoreshwa witonze ku nyoni zitwite n'izonsa.
6. Iyo ubushyuhe bw'umubiri bw'ingurube zirwaye buri hejuru, ishobora gukoreshwa hamwe n'imiti igabanya ububabare na dexamethasone, kandi ingaruka zikaba nziza kurushaho.Ese?
7. Mu gukumira no kuvura indwara y’ubuhumekero y’ingurube (PRDC), hari abantu basaba ko habaho guhuza florfenicol na amoxicillin, florfenicol na tylosin, na florfenicol na tylosin, ibi bikaba bidakwiye. , kuko mu rwego rw’imiti, byombi ntibishobora gukoreshwa icyarimwe. Ariko, florfenicol ishobora gukoreshwa hamwe na tetracyclines nka doxycycline.Ese?
8. Iki gicuruzwa gifite uburozi mu maraso. Nubwo kitazatera indwara yo kubura amaraso mu maraso, kugabanya ubukana bw'amaraso mu maraso bitewe nacyo bikunze kugaragara kurusha chloramphenicol (abafite ubumuga). Birabujijwe mu gihe cyo gukingirwa cyangwa mu matungo afite ikibazo gikomeye cy'ubudahangarwa bw'umubiri.Ese?
9. Kuyikoresha igihe kirekire bishobora gutera ibibazo by'igogora no kubura vitamine cyangwa ibimenyetso by'ubwandu bukabije.Ese?
10. Mu kwirinda no kuvura indwara z'ingurube, hakwiye kwitonderwa, kandi umuti utangwa hakurikijwe ingano n'uburyo bwo kuvura, kandi ntugomba gukoreshwa nabi kugira ngo wirinde ingaruka mbi.Ese?
11. Ku matungo afite ikibazo cy’impyiko, ingano y’impyiko igomba kugabanywa cyangwa igihe cyo kuyitanga cyongererwe igihe.Ese?
12. Mu gihe ubushyuhe buri hasi, byagaragaye ko igipimo cyo gushonga kiri buhoro; cyangwa umuti wateguwe ufite imvura ya florfenicol, ubushyuhe buke gusa (butarenze 45℃), byose bishobora gushonga vuba. Umuti wateguwe ni byiza kuwukoresha mu masaha 48.Ese?
Ni byiza cyane gukoresha uburyo bukwiye bwo gupima nk'uko bivugwa haruguru kandi ukareba urugero rwatanzwe. Inyamaswa imwe imwe ishobora kugira ikibazo cyo kubura ubushake bwo kurya by'igihe gito, kugabanya amazi cyangwa impiswi, ububabare buto aho iterwa mu mitsi ndetse n'ingaruka nke ku ngingo, byose bikaba bisanzwe kandi bigasubira uko bisanzwe nyuma yo guhagarika umuti.
Igihe cyo kohereza ubutumwa: Werurwe-28-2022