Florfenicolni antibiyotike yagutse, ifite ingaruka nziza zo guhagarika bagiteri nziza na bagiteri mbi. Kubwibyo, ubworozi bwinshi bwingurube bukunze gukoresha florfenicol kugirango wirinde cyangwa uvure ingurube mugihe cyindwara zikunze kubaho. abarwayi. Abakozi b'amatungo bo mu bworozi bw'ingurube bakoresha super-dose ya florfenicol mu kuvura cyangwa gukumira indwara batitaye ku ndwara, batitaye ku itsinda cyangwa icyiciro. Florfenicol ntabwo ari umuti, kandi igomba gukoreshwa neza kugirango igere ku ngaruka zifuzwa. Hano hepfo turamenyekanisha imyumvire isanzwe yo gukoresha florfenicol muburyo burambuye, twizeye ko izafasha benshi mubahinzi b'ingurube:
1. Antibacterial properties offlorfenicol
1. Ifite antibacterial nini cyane, kandi ifite ingaruka zikomeye zo kwica kuri Gram-positif ya bagiteri na bagiteri mbi, ndetse na anaerobic Gram-nziza ya bagiteri na spirochette mbi, rickettsia, amoeba, nibindi. Ingaruka zikomeye za antibacterial.
2. Muri vitro no mubushakashatsi bwa vivo bwerekana ko ibikorwa bya antibacterial ari byiza cyane kuruta imiti ya antibacterial.
3. Gukora vuba, florfenicol irashobora kugera kumiti ivura mumaraso nyuma yisaha 1 nyuma yo guterwa inshinge, kandi ibiyobyabwenge bishobora kugerwaho mumasaha 1.5-3; kumara igihe kinini, ibiyobyabwenge byamaraso bishobora gukomeza amasaha arenga 20 nyuma yubuyobozi bumwe.
4. Irashobora kwinjira mu nzitizi yubwonko bwamaraso, kandi ingaruka zayo zo kuvura indwara ya bagiteri meningite ntagereranywa nindi miti igabanya ubukana.
5. Ntabwo ifite uburozi ningaruka iyo ikoreshejwe muburyo bwateganijwe, irenga ibyago byo kubura amaraso make hamwe nuburozi buterwa na thiamphenicol, kandi ntibitera kwangiza inyamaswa nibiryo. Ikoreshwa mu kwanduza ibice bitandukanye byumubiri biterwa na bagiteri mu nyamaswa. Kuvura, harimo gukumira no kuvura indwara z’ubuhumekero za bagiteri, meningite, pleurisy, mastitis, indwara zo mu nda na syndrome ya nyuma y’ingurube.
2. Indwara ya bagiteri yanduye yaflorfenicol
1. Indwara z'ingurube aho florfenicol ikundwa
Iki gicuruzwa kirasabwa nk'umuti uhitamo umusonga w'ingurube, porcine yanduye pleuropneumonia n'indwara ya Haemophilus parasuis, cyane cyane mu kuvura bagiteri zirwanya fluoroquinolone n'izindi antibiyotike.
2. Florfenicol irashobora kandi gukoreshwa mukuvura indwara zingurube zikurikira
Irashobora kandi gukoreshwa mu kuvura indwara z'ubuhumekero ziterwa na Streptococcus zitandukanye (pneumoniya), Bordetella bronchiseptica (rinite atrophique), Mycoplasma pneumoniae (asima y'ingurube), n'ibindi.; salmonellose (piglet paratyphoid), colibacillose (asima y'ingurube) Indwara zifata igifu nka enterite iterwa n'impiswi z'umuhondo, impiswi zera, indwara y'ingurube) n'izindi bagiteri zoroshye. Florfenicol irashobora gukoreshwa mu kuvura izo ndwara z'ingurube, ariko ntabwo ariwo muti uhitamo izo ndwara z'ingurube, bityo ugomba gukoreshwa witonze.
3. Gukoresha nabiflorfenicol
1. Igipimo ni kinini cyane cyangwa gito cyane. Ingano nini ni uburozi, kandi dosiye ntoya ntacyo ikora.?
2. igihe ni kirekire. Bimwe murigihe kirekire gukoresha ibiyobyabwenge byinshi nta kubuza.
3.koresha ibintu, amakosa yo murwego. Kubiba inda n'ingurube zibyibushye zikoresha ibiyobyabwenge mu buryo butarobanuye, bigatera uburozi cyangwa ibisigazwa byibiyobyabwenge, bikavamo umusaruro muke ndetse nibiribwa.
4. Guhuza bidakwiye. Abantu bamwe bakunze gukoresha florfenicol hamwe na sulfonamide na cephalosporine. Niba ari siyanse kandi yumvikana birakwiye gushakisha.
5. Kugaburira kuvanze ntibivanze neza, bigatuma nta ngaruka zibiyobyabwenge cyangwa uburozi.
Icya kane, ikoreshwa ryaflorfenicolkwirinda
1.Ibicuruzwa ntibigomba gukoreshwa bifatanije na macrolide, lincosamide na diterpenoid igice cya sintetike ya antibiotike - Tiamulin, ishobora kubyara ingaruka mbi iyo ikoreshejwe hamwe.?
2. Iki gicuruzwa ntigishobora gukoreshwa hamweβ-lactone amine na fluoroquinolone, kubera ko iki gicuruzwa nikintu cyihuta cya bacteriostatike ikingira intungamubiri za poroteyine, kandi icya nyuma ni bagiteri yihuta cyane mugihe cyimyororokere. Mubikorwa byabanje, synthesis ya bagiteri ya protein ihagarikwa byihuse, bagiteri ihagarika gukura no kugwira, kandi ingaruka za bagiteri ziterwa na nyuma ziracika intege. Kubwibyo, mugihe ubuvuzi bukeneye kugira ingaruka zihuse zo kuboneza urubyaro, ntibushobora gukoreshwa hamwe.
3. Iki gicuruzwa ntigishobora kuvangwa na sodium ya sulfadiazine yo gutera inshinge. Ntigomba gukoreshwa ifatanije nibiyobyabwenge bya alkaline mugihe itanzwe kumunwa cyangwa mumitsi, kugirango wirinde kubora no gutsindwa. Ntibikwiye kandi gutera inshinge hamwe na tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, nibindi, kugirango wirinde kugwa no kugabanuka kwingirakamaro.
4. Kwangirika kw'imitsi na necrosis birashobora guterwa nyuma yo gutera inshinge. Kubwibyo, irashobora guterwa ubundi buryo mumitsi yimbitse yijosi nigituba, kandi ntabwo ari byiza gusubiramo inshinge kurubuga rumwe.
5. Kubera ko iki gicuruzwa gishobora kuba gifite intanga ngore, kigomba gukoreshwa ubwitonzi mu mbuto zitwite kandi zonsa.
6. Iyo ubushyuhe bwumubiri bwingurube zirwaye buri hejuru, burashobora gukoreshwa hamwe na antipyretic analgesics na dexamethasone, kandi ingaruka nibyiza.?
7. Mu gukumira no kuvura indwara y’ubuhumekero ya porcine (PRDC), abantu bamwe basaba guhuza florfenicol na amoxicillin, florfenicol na tylosine, na florfenicol na tylosine, bidakwiye. , kubera ko ukurikije ibya farumasi, byombi ntibishobora gukoreshwa hamwe. Nyamara, florfenicol irashobora gukoreshwa hamwe na tetracycline nka doxycycline.?
8. Iki gicuruzwa gifite uburozi bwa hematologiya. Nubwo bitazatera amagufa adasubirwaho marrow aplastique anemia, ihindagurika rya erythropoiesis iterwa nayo irasanzwe kuruta chloramphenicol (ubumuga). Yandujwe mugihe cyo gukingira cyangwa inyamaswa zifite ubudahangarwa bukabije.?
9. Gukoresha igihe kirekire birashobora gutera ikibazo cyigifu no kubura vitamine cyangwa ibimenyetso bya superinfection.?
10. Mu gukumira no kuvura indwara z’ingurube, hagomba kwitabwaho, kandi imiti igomba gutangwa hakurikijwe igipimo cyagenwe n’ubuvuzi, kandi ntigomba gukoreshwa nabi kugira ngo hatagira ingaruka mbi.?
11. Ku nyamaswa zifite impyiko zidahagije, igipimo kigomba kugabanuka cyangwa intera yubuyobozi igomba kongerwa.?
12. Mugihe cy'ubushyuhe buke, usanga igipimo cyo gusesa gitinda; cyangwa igisubizo cyateguwe gifite imvura ya florfenicol, gushyushya gake (ntibirenze 45℃), byose birashobora guseswa vuba. Igisubizo cyateguwe gikoreshwa neza mumasaha 48.?
Ni byiza cyane gukoresha ifishi ikwiye ukurikije intangiriro yavuzwe haruguru hanyuma ukareba dosiye isabwa. Inyamaswa ku giti cye zishobora gutakaza ubushake bwo kurya, kugabanuka gufata amazi cyangwa impiswi, ububabare buke aho batewe inshinge ndetse nuduce duto duto, ibyo byose nibisanzwe kandi bigasubira mubisanzwe nyuma yo guhagarika ibiyobyabwenge.
Igihe cyo kohereza: Werurwe-28-2022