Tilmicosine isa nkibikoresho fatizo, nigute dushobora gutandukanya itandukaniro ryabo?

Indwara y'ubuhumekero y'ingurube yamye ari indwara igoye yibasira ba nyiri ubworozi bw'ingurube.Indwara ya etiologiya iragoye, virusi ziratandukanye, ubwinshi ni bwinshi, kandi gukumira no kugenzura biragoye, bizana igihombo kinini mu bworozi bw'ingurube.Mu myaka yashize, indwara z’ubuhumekero bw’ingurube akenshi zigaragaza indwara zivanze, bityo tumenyereye kubyita syndrome de santrale y’ubuhinzi bw’ingurube.Indwara ziterwa na virusi zirimo Mycoplasma, Haemophilus parasuis, Actinobacillus pleuropneumoniae, ugutwi k'ubururu, circovirus n'ibicurane by'ingurube.

Mu gukumira no kuvura indwara z'ubuhumekero, tilmicosine igira ingaruka nziza

Indwara z'ubuhumekero z'ingurube zigabanyijemo ahanini bagiteri, virusi na mycoplasma.Kuri mycoplasma na porcine yanduye pleuropneumonia, antibiyotike isanzwe isanzwe yateye imbaraga zo kurwanya, kandi muri rusange hashyizweho ibisekuru bishya bya antibiotike mu rwego rwo gukumira no kuvura indwara z’ubuhumekero z’ingurube.Kurugero, tilmicosine, doxycycline, tyvalomycine, nibindi, hamwe nubuvuzi gakondo bwa virusi ya virusi ya virusi, bigira ingaruka zikomeye.Ubushakashatsi bwerekanye ko tilmicosine igira ingaruka zimwe na zimwe za virusi, kandi igira ingaruka nziza ku kurwanya indwara y’ubuhumekero y’ubuhumekero ifitanye isano na porcine PRRS.

Tilmicosinifite inzira yimbitse kandi ifite inyungu nyinshi zo gutwikira kabiri.

Nkuko twese tubizi, tilmicosine ni umwe mu miti ikora neza mu kurwanya indwara z’ubuhumekero mu bworozi bw’ingurube.Nyamara, ingaruka za tilmicosine zitandukanye ku isoko ntizisa.Kuki ibi?Nigute dushobora gutandukanya hagati yabo?Tuvuge iki ku itandukaniro?Kuri tilmicosine, ibikoresho fatizo birasa, kandi nta tandukaniro ryinshi.Kugaragaza ingaruka zibicuruzwa, biterwa ahanini nuburyo bwo gukora.Mubikorwa byo gukora ibicuruzwa, guharanira ingaruka nziza yibicuruzwa byabaye inzira nyamukuru.inzira y'iterambere.

Ubwiza-bwizatilmicosinigomba kugira ibintu bine biranga: ingurube zikunda kurya, kurinda igifu, gusohora amara no kurekura buhoro.

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Tandukanya isura

1. Ibice bya tilmicosine bidafunze ni byiza cyane kandi byoroshye gushonga mubushyuhe bwicyumba, mugihe uduce twa tilmicosine dusize twinshi kandi bigoye gushonga mubushyuhe bwicyumba.

2. Tilmicosine nziza (nka Chuankexin yashizwemo na microcapsules ebyiri) ifite ibice bimwe kandi bizengurutse.Muri rusange, ibice bya tilmicosine bitwikiriye biratandukanye mubunini no muburinganire.

Tandukanya uburyohe mumunwa (palatable nziza)

Tilmicosinuburyohe bukaze, kandi tilmicosine idapfundikijwe ntabwo ikwiriye gutangwa kumanwa.Tilmicosine ifite uburyohe bukaze mu kanwa ntabwo igera gusa ku miti itifuzwa gusa, ahubwo inagira ingaruka zikomeye ku kugaburira ingurube no kwangiza byinshi.Imyanda.

Tandukanya na gastric solubilité na enteric solubility

1. Igipfundikizo cya tilmicosine kigabanyijemo ibice bya enteric (birwanya aside ariko ntibirwanya alkali) hamwe na gastric-soluble (ntabwo acide- na alkali irwanya).Gastric-soluble (idashobora kurwanya aside na alkali) isize tilmicosine izashonga kandi irekurwe na aside gastrica mu gifu, kandi nibimara kurekurwa, bizatera mucosa gastrica gusohora umutobe wa gastric, kandi umutobe wa gastrica urashobora gutera byoroshye. kuva amaraso mu gifu n'ibisebe byo mu gifu.Niba imiti yashonze mu gifu ikarekurwa hakiri kare, bioavailable yumuti nayo izagabanuka cyane.Muri rusange, imikorere yibiyobyabwenge byashonga mu gifu bizagabanuka hejuru ya 10% ugereranije n’amara.Ibi byongera cyane ikiguzi cyimiti.

2. Kwinjiza enteric (anti-acide ariko ntabwo birwanya alkali) Ipitingi irashobora gushonga hanyuma ikarekurwa binyuze mumyanya ya acide gastricike idashobora gukama mubidukikije bya alkaline yo mu mara, bikarinda ingaruka zitandukanye hamwe nindwara z'umutima ziterwa no kurekurwa hakiri kare mu gifu.Muri icyo gihe, bioavailable yimiti mu mara iratera imbere.Kurekura vuba mu mara.

Enteric coating ikoresha ibikoresho bitandukanye byo gutwikisha hamwe nibikorwa, kandi uburyo bwo kurekura amara nabwo buratandukanye.Ipitingi isanzwe irashonga igice hanyuma ikarekurwa mumyanya yigifu nigisubizo cya gastrica, ibyo bikaba bitandukanye cyane ningaruka ziterwa na microcapsule ya layer ebyiri, kandi igipimo cyo kwinjirira mumara yihuta.